Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIP3ZV)

• Drug Name: Fenoterol Drug Info
• Synonyms: Berotec; Berotek; Fenoterolum; Phenoterol; TH 1165A; Berotec (TN); Fenoterolum [INN-Latin]; P-Hydroxyphenylorciprenaline; Th-1165a; Fenoterol (USAN/INN); Fenoterol [USAN:BAN:INN]; P-Hydroxyphenyl-orciprenaline; 1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-((4-hydroxyphenyl)isopropylamino)ethane; 1-(p-Hydroxyphenyl)-2-((beta-hydroxy-beta-(3',5'-dihydroxyphenyl))ethyl)aminopropane; 3,5-Dihydroxy-alpha-(((p-hydroxy-alpha-methylphenethyl)amino)methyl)benzyl alcohol; 5-(1-hydroxy-2-{[1-(4-hydroxyphenyl)propan-2-yl]amino}ethyl)benzene-1,3-diol; 5-(1-hydroxy-2-{[2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)benzene-1,3-diol; 5-[1-hydroxy-2-[1-(4-hydroxyphenyl)propan-2-ylamino]ethyl]benzene-1,3-diol; 5-{1-Hydroxy-2-[2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-benzene-1,3-diol
• Therapeutic Class: Bronchodilator Agents
• Cross-matching ID:
  PubChem CID: 3343
  ChEBI ID: CHEMBL32800
  CAS Number: CAS 13392-18-2
  TTD Drug ID: D04XEG
  VARIDT Drug ID: DR01356

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Asthma	2.22	0.00e+0	25/31 (80.65%)	CD40;HLA-DQA1;HLA-DPA1;...
Intestinal immune network for IgA production	2.19	0.00e+0	38/48 (79.17%)	CD40;HLA-DQA1;HLA-DPA1;...
Systemic lupus erythematosus	2.09	0.00e+0	45/135 (33.33%)	CD40;HLA-DQA1;HLA-DPA1;...
Staphylococcus aureus infection	2.03	0.00e+0	72/95 (75.79%)	HLA-DQA1;HLA-DPA1;HLA-DQB1;...
Legionellosis	1.96	3.84e-3	51/57 (89.47%)	HSPA8;CYCS;CXCL2;...
Allograft rejection	1.90	6.40e-3	32/38 (84.21%)	CD40;HLA-DQA1;HLA-DPA1;...
Viral myocarditis	1.80	1.51e-2	53/60 (88.33%)	CD40;HLA-DQA1;HLA-DPA1;...
Leishmaniasis	1.79	1.32e-2	67/77 (87.01%)	HLA-DQA1;HLA-DPA1;HLA-DQB1;...
Type I diabetes mellitus	1.78	1.39e-2	38/43 (88.37%)	HLA-DQA1;HLA-DPA1;HLA-DQB1;...
Autoimmune thyroid disease	1.76	1.92e-2	46/53 (86.79%)	CD40;HLA-DQA1;HLA-DPA1;...
DNA replication	1.76	1.74e-2	34/36 (94.44%)	PCNA;MCM7;RNASEH2A;...
Toxoplasmosis	1.75	1.92e-2	103/112 (91.96%)	HSPA8;GNAI1;CD40;...
Protein digestion and absorption	1.69	3.40e-2	78/103 (75.73%)	COL5A1;COL4A5;CPB1;...
Antigen processing and presentation	1.67	3.98e-2	60/78 (76.92%)	HSPA8;HSPA4;HLA-DQA1;...
N-Glycan biosynthesis	1.66	4.29e-2	38/50 (76%)	DPAGT1;ALG8;ALG3;...
RNA polymerase	1.65	4.32e-2	23/31 (74.19%)	POLR1D;POLR2I;POLR1C;...
Mismatch repair	1.64	4.74e-2	22/23 (95.65%)	PCNA;RPA2;MLH1;...
Glycine, serine and threonine metabolism	-2.15	0.00e+0	31/40 (77.5%)	SHMT2;PSPH;DLD;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼