Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIP9DN)

Drug Name
Indatraline Drug Info
Synonyms
Indatraline; Lu 19005; CHEMBL341898; 86939-10-8; Indatralinum; Indatraline [INN]; (+)-Indatraline; Lu-19-005; (-)-trans-3-(3,4-dichlorophenyl)-n-methyl-1-indanamine; Lopac-I-119; AC1Q3O5Q; Lopac0_000684; SCHEMBL9252640; AC1L2Q22; DTXSID4043981; CHEBI:94467; (+-)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine; ZINC3872906; BDBM50095618; PDSP2_001486; PDSP1_001502; CCG-204769; API0009127; NCGC00025223-04; NCGC00025223-03; NCGC00015532-01; NCGC00025223-02; 97229-15-7; 3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hcl; UNII-4U40Y96J1Z c
Cross-matching ID
PubChem CID
126280
ChEBI ID
CHEMBL94467
CAS Number
CAS 86939-10-8
TTD Drug ID
D08NZE
VARIDT Drug ID
DR00934

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.45 0.00e+0 19/20 (95%) NSDHL;MSMO1;DHCR7;...
Terpenoid backbone biosynthesis 1.95 0.00e+0 18/22 (81.82%) HMGCS1;FDPS;IDI1;...
ECM-receptor interaction 1.86 1.91e-2 80/88 (90.91%) FN1;THBS4;VWF;...
Complement and coagulation cascades 1.80 2.87e-2 76/85 (89.41%) CLU;TFPI;CFD;...
Ascorbate and aldarate metabolism -1.78 4.47e-2 15/30 (50%) UGT2A3;AKR1A1;ALDH2;...
Ribosome biogenesis in eukaryotes -1.82 3.73e-2 52/108 (48.15%) RPP40;XPO1;NAT10;...
DNA replication -1.85 3.31e-2 34/36 (94.44%) RFC3;MCM4;POLD1;...
Spliceosome -1.88 3.73e-2 101/150 (67.33%) ACIN1;LSM3;DHX38;...
Cell cycle -1.99 0.00e+0 110/124 (88.71%) GSK3B;CDK2;MCM7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H