Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIRPSA)

Drug Name
Mitoglitazone Drug Info
Synonyms MSDC-0160; Mitoglitazone (TN)
Cross-matching ID
PubChem CID
10429242
ChEBI ID
CHEMBL146624
CAS Number
CAS 146062-49-9
TTD Drug ID
D00SWQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.32 0.00e+0 93/133 (69.92%) ATP6V1D;NDUFA1;COX7B;...
African trypanosomiasis 2.08 5.09e-3 32/37 (86.49%) PRKCA;PLCB1;PLCB3;...
Proteasome 1.96 1.02e-2 44/46 (95.65%) SEM1;PSMD12;PSMA2;...
Parkinson disease 1.96 7.63e-3 176/249 (70.68%) TUBB2A;CYCS;NDUFA1;...
Prion disease 1.82 3.05e-2 209/273 (76.56%) TUBB2A;NCAM1;C7;...
Diabetic cardiomyopathy 1.82 2.71e-2 162/203 (79.8%) GAPDH;AGTR1;PRKCA;...
Huntington disease 1.80 2.91e-2 233/306 (76.14%) TUBB2A;POLR2F;PLCB1;...
Glycolysis / Gluconeogenesis -1.78 2.95e-2 56/67 (83.58%) HK3;AKR1A1;PGK1;...
Lysosome -1.79 3.15e-2 115/128 (89.84%) HGSNAT;AP4S1;SORT1;...
Valine, leucine and isoleucine degradation -1.80 3.93e-2 42/48 (87.5%) ACADM;BCAT2;BCAT1;...
Hypertrophic cardiomyopathy -1.82 4.26e-2 81/90 (90%) CACNA1F;ITGB8;EMD;...
Staphylococcus aureus infection -1.87 2.46e-2 72/95 (75.79%) C5AR1;KRT14;FCGR2B;...
Tryptophan metabolism -1.93 2.95e-2 35/42 (83.33%) CYP1A1;KMO;CAT;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H