Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMITQS0)

Drug Name
Lopinavir Drug Info
Synonyms
AIDS032937; Aluvia (TN); Aluviran; Kaletra (TN); Koletra; LPV; Lopinavir (JAN/USAN/INN); Lopinavir [USAN:INN:BAN]; RS-346; A 157378; A 157378.0; A-157378-0; A-157378.0; ABT 157378; ABT 378; ABT-378; ABT-378
Therapeutic ClassAnti-HIV Agents
Cross-matching ID
PubChem CID
92727
ChEBI ID
CHEMBL729
CAS Number
CAS 192725-17-0
TTD Drug ID
D0U5GB
VARIDT Drug ID
DR00290
INTEDE Drug ID
DR0976

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.31 0.00e+0 127/171 (74.27%) HERPUD1;P4HB;SEC24D;...
Protein export 2.25 0.00e+0 17/23 (73.91%) SRPRB;SEC63;HSPA5;...
DNA replication 2.12 0.00e+0 34/36 (94.44%) PCNA;PRIM1;POLE2;...
Fanconi anemia pathway 2.05 0.00e+0 36/54 (66.67%) PALB2;RAD51;BRCA1;...
N-Glycan biosynthesis 2.00 0.00e+0 38/50 (76%) DPAGT1;ALG5;STT3A;...
Ribosome biogenesis in eukaryotes 1.99 0.00e+0 52/108 (48.15%) NOP56;DKC1;IMP3;...
Spliceosome 1.87 5.70e-3 101/150 (67.33%) LSM5;HSPA6;SRSF7;...
Homologous recombination 1.86 5.98e-3 35/41 (85.37%) PALB2;RAD51;BRCA1;...
Base excision repair 1.84 6.21e-3 29/33 (87.88%) PCNA;APEX1;POLE2;...
Amino sugar and nucleotide sugar metabolism 1.80 7.18e-3 38/48 (79.17%) GFPT1;GMDS;UAP1;...
Various types of N-glycan biosynthesis 1.76 1.74e-2 26/39 (66.67%) STT3A;MAN1C1;DAD1;...
Histidine metabolism 1.74 1.93e-2 16/22 (72.73%) HNMT;MAOB;ALDH9A1;...
Fructose and mannose metabolism 1.74 1.84e-2 30/33 (90.91%) GMDS;HK2;AKR1B10;...
Biosynthesis of unsaturated fatty acids 1.73 1.82e-2 21/27 (77.78%) SCD;ELOVL6;SCD5;...
Ascorbate and aldarate metabolism 1.72 1.81e-2 15/30 (50%) ALDH9A1;AKR1A1;ALDH2;...
Mismatch repair 1.66 3.09e-2 22/23 (95.65%) PCNA;RFC4;EXO1;...
Drug metabolism 1.63 3.71e-2 78/151 (51.66%) MAOB;GSTA1;NME1;...
Non-homologous end-joining 1.62 3.81e-2 11/13 (84.62%) FEN1;XRCC5;DCLRE1C;...
Pathways in cancer -1.64 3.17e-2 474/531 (89.27%) TCF7L1;MAP2K2;GNB1;...
Axon guidance -1.65 3.12e-2 151/182 (82.97%) PRKCZ;SEMA5A;SRC;...
Malaria -1.66 2.98e-2 44/50 (88%) ACKR1;KLRB1;SELP;...
Shigellosis -1.66 3.05e-2 180/246 (73.17%) ACTR3;IFNB1;ARPC1A;...
Hepatitis C -1.67 2.98e-2 139/157 (88.54%) E2F3;IFNB1;MAP2K2;...
Hippo signaling pathway -1.68 2.87e-2 120/186 (64.52%) PPP1CC;PARD6B;FGF1;...
Chronic myeloid leukemia -1.69 2.89e-2 72/76 (94.74%) E2F3;MAP2K2;NFKBIA;...
Adherens junction -1.70 2.76e-2 63/71 (88.73%) TCF7L1;SNAI2;NLK;...
Salmonella infection -1.70 2.83e-2 198/249 (79.52%) DYNC1H1;TUBB1;ACTR3;...
Hypertrophic cardiomyopathy -1.73 2.24e-2 81/90 (90%) ITGB7;CACNG1;CACNG4;...
Cell adhesion molecules -1.73 2.35e-2 118/148 (79.73%) SELP;CD22;CLDN5;...
Thyroid cancer -1.74 2.23e-2 36/37 (97.3%) TCF7L1;MAP2K2;GADD45B;...
Primary immunodeficiency -1.74 2.29e-2 33/38 (86.84%) CD3E;CD79A;CD19;...
Endocytosis -1.75 2.35e-2 198/252 (78.57%) FOLR3;PRKCZ;SRC;...
Apoptosis -1.76 1.98e-2 126/168 (75%) HTRA2;DIABLO;MAP2K2;...
Cardiac muscle contraction -1.77 1.96e-2 64/87 (73.56%) SLC9A7;CACNG2;COX7A1;...
Pancreatic cancer -1.78 1.85e-2 75/76 (98.68%) PIK3R1;RAC1;EGF;...
Thyroid hormone signaling pathway -1.79 1.90e-2 112/121 (92.56%) HIF1A;GSK3B;NCOR1;...
Endocrine and other factor-regulated calcium reabsorpti... -1.79 2.06e-2 49/53 (92.45%) ATP2B3;DNM2;ATP2B2;...
Endometrial cancer -1.79 2.03e-2 56/58 (96.55%) TCF7L1;MAP2K2;GADD45B;...
Basal cell carcinoma -1.80 2.12e-2 41/63 (65.08%) FZD6;WNT7A;GSK3B;...
Colorectal cancer -1.80 2.09e-2 84/86 (97.67%) PIK3R1;RAC1;EGF;...
ECM-receptor interaction -1.87 1.32e-2 80/88 (90.91%) RELN;COL4A1;ITGB6;...
Arrhythmogenic right ventricular cardiomyopathy -1.87 1.51e-2 70/77 (90.91%) ITGB7;CACNG1;CACNG4;...
Dilated cardiomyopathy -1.88 1.76e-2 86/96 (89.58%) ITGB7;CACNG1;CACNG4;...
Lysosome -1.90 1.65e-2 115/128 (89.84%) DNASE2B;LAMP3;GAA;...
Human papillomavirus infection -1.90 2.06e-2 284/331 (85.8%) GSK3B;ITGB7;PTGS2;...
Regulation of actin cytoskeleton -1.94 1.57e-2 185/218 (84.86%) SRC;PDGFB;ARHGEF1;...
Focal adhesion -1.99 0.00e+0 180/201 (89.55%) PIP5K1C;ARHGAP35;ITGB1;...
Small cell lung cancer -2.12 0.00e+0 90/92 (97.83%) PTGS2;COL4A4;E2F3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H