Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIUW25)

• Drug Name: Granisetron Drug Info
• Synonyms: BRL-43694; Kytril (TN); Granisetron (USAN/INN); 1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide; 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
• Therapeutic Class: Antiemetics
• Cross-matching ID:
  PubChem CID: 5284566
  ChEBI ID: CHEMBL5537
  CAS Number: CAS 109889-09-0
  TTD Drug ID: D0J5KF
  VARIDT Drug ID: DR00439
  INTEDE Drug ID: DR0788
  ACDINA Drug ID: D00614

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	2.28	0.00e+0	48/60 (80%)	MT1E;MT1F;MT1G;...
Proteasome	2.17	0.00e+0	44/46 (95.65%)	PSMA6;PSMA3;PSMA5;...
Parkinson disease	1.94	2.75e-3	176/249 (70.68%)	UCHL1;PSMA6;NDUFB5;...
Oxidative phosphorylation	1.89	6.18e-3	93/133 (69.92%)	NDUFB5;COX5B;NDUFA8;...
Porphyrin and chlorophyll metabolism	1.78	2.47e-2	23/43 (53.49%)	UGT2B28;HMBS;FXN;...
Purine metabolism	1.78	2.20e-2	102/129 (79.07%)	NUDT9;ADA;GUCY1B1;...
Drug metabolism	1.72	3.88e-2	78/151 (51.66%)	GSTO1;ADH5;NAT1;...
Notch signaling pathway	-1.67	4.70e-2	49/59 (83.05%)	DTX3;TLE1;PTCRA;...
ECM-receptor interaction	-1.92	3.53e-2	80/88 (90.91%)	ITGA2;THBS4;ITGA7;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼