Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIUYFH)

• Drug Name: Sulfapyridine Drug Info
• Synonyms: Adiplon; Coccoclase; Dagenan; Eubasin; Eubasinum; Haptocil; Piridazol; Plurazol; Pyriamid; Pyridazol; Relbapiridina; Ronin;Septipulmon; Solfapiridina; Streptosilpyridine; Sulfapiridina; Sulfapyridinum; Sulfidin; Sulfidine; Sulphapyridin; Sulphapyridine; Thioseptal; Trianon; Solfapiridina [DCIT]; M and B 693; A-499; ALBB-006215; M + B 693; M&B 693; M+B 693; Sulfapiridina [INN-Spanish]; Sulfapyridine (TN); Sulfapyridinum [INN-Latin]; AO-801/41077453; N(1)-Pyridylsulfanilamide; N(sup1)-Pyridylsulfanilamide; N-2-Pyridylsulfanilamide; N1-2-Pyridylsulfanilamide; Sulfapyridine (USP/INN); Sulfapyridine [USAN:INN:BAN]; N'-2-Pyridylsulfanilide; N(1)-2-Pyridylsulfanilamide; N(sup 1)-2-Pyridylsulfanilamide; N1-(Pyridin-2-yl)sulfanilamide; Sulfanilamide, N1-2-pyridyl-(8CI); 2-(4-Aminobenzenesulfonamido)pyridine; 2-(p-Aminobenzenesulphonamido)pyridine; 2-Sulfanilamidopyridin; 2-Sulfanilamidopyridin [German]; 2-Sulfanilamidopyridine; 2-Sulfanilyl aminopyridine; 2-Sulfanilylaminopyridine; 2-Sulfapyridine; 4-(2-Pyridinylsulfonyl)aniline; 4-AMINO-N-2-PYRIDINYLBENZENESULFONAMIDE; 4-Amino-N,2-pyridinylbenzenesulfonamide; 4-Amino-N-2-pyridinyl-benzenesulfonamide; 4-Amino-N-[2-pyridyl]benzene sulfonamide; 4-[(2-Pyridylamino)sulfonyl]aniline; 4-amino-N-(pyridin-2-yl)benzenesulfonamide; 4-amino-N-pyridin-2-yl-benzenesulfonamide; 4-amino-N-pyridin-2-ylbenzenesulfonamide
• Therapeutic Class: Dermatologic Agents
• Cross-matching ID:
  PubChem CID: 5336
  ChEBI ID: CHEMBL700
  CAS Number: CAS 144-83-2
  TTD Drug ID: D0D4CY
  INTEDE Drug ID: DR1512

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.39	0.00e+0	34/36 (94.44%)	POLE2;PRIM1;FEN1;...
Base excision repair	1.89	8.63e-3	29/33 (87.88%)	PARP2;POLE2;APEX1;...
Homologous recombination	1.86	1.15e-2	35/41 (85.37%)	NBN;BRCA1;RAD54B;...
Alanine, aspartate and glutamate metabolism	-1.76	3.05e-2	27/37 (72.97%)	CPS1;GFPT1;ALDH4A1;...
Nicotinate and nicotinamide metabolism	-1.76	3.48e-2	25/35 (71.43%)	NT5E;CD38;NMRK1;...
Lysosome	-1.76	4.06e-2	115/128 (89.84%)	CD68;FUCA1;LAPTM4A;...
Vitamin digestion and absorption	-1.92	6.65e-3	17/24 (70.83%)	SCARB1;APOA4;SLC19A2;...
Complement and coagulation cascades	-2.07	0.00e+0	76/85 (89.41%)	CD46;MBL2;C9;...
Cholesterol metabolism	-2.07	0.00e+0	44/50 (88%)	ANGPTL8;SOAT2;LIPA;...
Arginine biosynthesis	-2.15	0.00e+0	17/22 (77.27%)	GLS2;CPS1;ARG2;...
Steroid biosynthesis	-2.27	0.00e+0	19/20 (95%)	NSDHL;SOAT2;LIPA;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Show ▼