Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIV8CT)

Drug Name
Parecoxib Drug Info
Synonyms
Parecoxib; SC-69124; Dynastat; Valus-P; Vorth-P; SC 69124; UNII-9TUW81Y3CE; 9TUW81Y3CE; Parecoxib [USAN:INN:BAN]; CHEBI:73038; N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propionamide; Parocoxib; N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonylpropanamide; Propanamide, N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)-; N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide; N-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide; parecoxibum; Valdecoxib Impurity J; Parecoxib (
Cross-matching ID
PubChem CID
119828
ChEBI ID
CHEMBL73038
CAS Number
CAS 198470-84-7
TTD Drug ID
D05UWI
INTEDE Drug ID
DR1242

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
RNA polymerase -1.80 4.85e-2 23/31 (74.19%) POLR2B;POLR2K;POLR2C;...
PPAR signaling pathway -1.82 3.13e-2 66/74 (89.19%) ADIPOQ;ME3;RXRB;...
Primary bile acid biosynthesis -1.90 1.68e-2 15/17 (88.24%) ACOT8;AKR1C4;BAAT;...
Steroid biosynthesis -2.02 1.12e-2 19/20 (95%) DHCR24;SQLE;FDFT1;...
Coronavirus disease -2.12 5.59e-3 215/232 (92.67%) RPS3A;RPS19;IL2;...
Ribosome -2.56 0.00e+0 113/158 (71.52%) RPS10;RPL37A;MRPL17;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H