Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIV9ZE)

Drug Name
LOXORIBINE Drug Info
Synonyms AOG; Loxoribine < Rec INN; RWJ-21757; 7-(2-Propenyl)-8-oxo-7,8-dihydroguanosine; 7-Allyl-2-amino-9-beta-D-ribofuranosylpurine-6,8(1H,9H)-dione; 7-Allyl-8-oxo-7,8-dihydroguanosine; 7A8OGua
Cross-matching ID
PubChem CID
135410906
ChEBI ID
CHEMBL292008
CAS Number
CAS 121288-39-9
TTD Drug ID
D04EIF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Lysosome -1.72 3.83e-2 115/128 (89.84%) GALNS;CTSA;ABCB9;...
D-Glutamine and D-glutamate metabolism -1.74 3.31e-2 5/5 (100%) GLS;GLUD2;GLUD1
Synaptic vesicle cycle -1.76 3.09e-2 63/78 (80.77%) STX2;SLC6A11;SLC6A13;...
B cell receptor signaling pathway -1.90 5.57e-3 71/81 (87.65%) FCGR2B;KRAS;CD72;...
Phagosome -1.95 4.64e-3 118/152 (77.63%) NCF4;HLA-DPB1;RAB5C;...
Vibrio cholerae infection -2.01 3.09e-3 44/50 (88%) ATP6V1H;ADCY9;ATP6V1F;...
Collecting duct acid secretion -2.10 0.00e+0 22/27 (81.48%) CLCNKB;ATP6V1F;ATP6V1B1;...
Steroid biosynthesis -2.10 0.00e+0 19/20 (95%) SC5D;CYP51A1;SOAT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H