Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIVJ0D)

Drug Name
Pseudoephedrine Drug Info
Synonyms
Balminil Decongestant Syrup; Dimetapp Decongestant; Dimetapp Decongestant Pediatric Drops; Drixoral Nasal Decongestant; Pseudoephedrine Ephedrine; Sudafed Decongestant Extra Strength; Triaminic AM Decongestant Formula; Triaminic Infant Oral Decongestant Drops; Efidac 24 PseudoephedrineHcl; Sudafed Decongestant 12 Hour; Pseudoefedrina [INN-Spanish]; Pseudoephedrine (INN); Pseudoephedrine [INN:BAN]; Pseudoephedrine d-form; Pseudoephedrinum [INN-Latin]; Sudafed (TN); Alpha-(1-(Methylamino)ethyl)benzyl alcohol; D-psi-2-Methylamino-1-phenyl-1-propanol; Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)-(9CI); (+)-(1S,2S)-Pseudoephedrine; (1S,2S)-(+)-Pseudoephedrine; (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol; (1S,2S)-2-Methylamino-1-phenyl-1-propanol; (1S,2S)-Pseudoephedrine; (1S,2S)-Pseudoephedrine, polymer-bound
Cross-matching ID
PubChem CID
7028
ChEBI ID
CHEMBL51209
CAS Number
CAS 90-82-4
TTD Drug ID
D00HHS
INTEDE Drug ID
DR1369
ACDINA Drug ID
D00568

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Fatty acid degradation 2.08 0.00e+0 40/43 (93.02%) ADH1C;ECHS1;ACSL5;...
Complement and coagulation cascades 2.02 1.05e-2 76/85 (89.41%) CFI;CFH;C4BPA;...
Lysine degradation 1.95 1.40e-2 51/63 (80.95%) MECOM;PLOD2;DLD;...
Glycolysis / Gluconeogenesis 1.94 1.05e-2 56/67 (83.58%) ADH1C;DLD;GPI;...
Basal cell carcinoma 1.94 8.43e-3 41/63 (65.08%) WNT5A;PTCH1;FZD5;...
Mismatch repair 1.90 8.78e-3 22/23 (95.65%) LIG1;MSH6;POLD4;...
DNA replication 1.89 1.05e-2 34/36 (94.44%) LIG1;MCM3;POLD4;...
beta-Alanine metabolism 1.87 1.32e-2 25/30 (83.33%) ECHS1;CNDP2;ACOX1;...
Tryptophan metabolism 1.85 1.40e-2 35/42 (83.33%) CYP1A2;TDO2;DLD;...
Steroid hormone biosynthesis 1.83 1.47e-2 43/61 (70.49%) AKR1C3;AKR1C1;AKR1C2;...
Fructose and mannose metabolism 1.83 1.44e-2 30/33 (90.91%) SORD;AKR1B10;PFKFB3;...
Propanoate metabolism 1.80 1.40e-2 30/34 (88.24%) DLD;ECHS1;BCKDHA;...
Folate biosynthesis 1.80 1.38e-2 23/26 (88.46%) AKR1C3;AKR1B10;FPGS;...
Breast cancer 1.74 2.56e-2 119/147 (80.95%) WNT5A;IGF1;KIT;...
Pentose and glucuronate interconversions 1.73 2.88e-2 17/34 (50%) SORD;AKR1B10;DCXR;...
Valine, leucine and isoleucine degradation 1.70 3.69e-2 42/48 (87.5%) DLD;MCCC2;ECHS1;...
Glyoxylate and dicarboxylate metabolism 1.66 4.96e-2 23/30 (76.67%) DLD;GLUL;PCCA;...
Steroid biosynthesis -2.24 0.00e+0 19/20 (95%) FDFT1;EBP;TM7SF2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H