General Information of Drug (ID: DMIXABW)

Drug Name
Genz-644282 Drug Info
Synonyms Genz-644283; Anticancer compound (cancer), Genzyme
Cross-matching ID
PubChem CID
10294813
CAS Number
CAS 529488-28-6
TTD Drug ID
D0A1LS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Allograft rejection 2.42 0.00e+0 32/38 (84.21%) HLA-B;HLA-F;HLA-C;...
p53 signaling pathway 2.40 0.00e+0 63/73 (86.3%) CDKN1A;DDB2;SESN1;...
Graft-versus-host disease 2.39 0.00e+0 32/42 (76.19%) HLA-B;HLA-F;HLA-C;...
Autoimmune thyroid disease 2.38 0.00e+0 46/53 (86.79%) HLA-B;HLA-F;HLA-C;...
Epstein-Barr virus infection 2.31 0.00e+0 189/202 (93.56%) CDKN1A;HLA-B;DDB2;...
Herpes simplex virus 1 infection 2.31 0.00e+0 165/498 (33.13%) HLA-B;HLA-F;IRF9;...
Type I diabetes mellitus 2.28 0.00e+0 38/43 (88.37%) HLA-B;HLA-F;HLA-C;...
Cytosolic DNA-sensing pathway 2.18 0.00e+0 52/63 (82.54%) IL1B;POLR2H;POLR2L;...
Influenza A 2.17 0.00e+0 156/172 (90.7%) MX1;IRF9;IL1B;...
Viral myocarditis 2.09 0.00e+0 53/60 (88.33%) CXADR;HLA-B;HLA-F;...
Measles 2.04 0.00e+0 133/139 (95.68%) MX1;IRF9;TP53;...
Toll-like receptor signaling pathway 1.98 8.30e-4 94/104 (90.38%) IL1B;CASP8;CXCL8;...
Lysosome 1.96 1.53e-3 115/128 (89.84%) FUCA1;NEU1;ASAH1;...
Legionellosis 1.95 1.42e-3 51/57 (89.47%) IL1B;CASP8;CXCL8;...
Apoptosis 1.93 1.99e-3 126/168 (75%) GADD45A;TP53;FAS;...
NF-kappa B signaling pathway 1.93 1.87e-3 90/104 (86.54%) RELB;GADD45A;IL1B;...
Rheumatoid arthritis 1.92 1.76e-3 78/93 (83.87%) IL1B;HLA-DQA1;CXCL8;...
Antigen processing and presentation 1.91 1.66e-3 60/78 (76.92%) HLA-B;IFI30;HLA-F;...
Pertussis 1.91 1.57e-3 64/76 (84.21%) IL1B;CXCL8;MYD88;...
Leishmaniasis 1.90 1.49e-3 67/77 (87.01%) MARCKSL1;IL1B;HLA-DQA1;...
Staphylococcus aureus infection 1.90 1.90e-3 72/95 (75.79%) CFB;HLA-DQA1;KRT16;...
Hepatitis C 1.89 2.26e-3 139/157 (88.54%) CDKN1A;MX1;IFIT1;...
Necroptosis 1.88 2.60e-3 113/159 (71.07%) IRF9;IL1B;SLC25A4;...
Tuberculosis 1.83 3.73e-3 159/180 (88.33%) CLEC7A;IL1B;HLA-DQA1;...
Taurine and hypotaurine metabolism 1.79 5.58e-3 8/11 (72.73%) ADO;CSAD;GAD1
Kaposi sarcoma-associated herpesvirus infection 1.78 6.13e-3 172/193 (89.12%) CDKN1A;HLA-B;HLA-F;...
Base excision repair 1.78 5.90e-3 29/33 (87.88%) POLE3;FEN1;NEIL1;...
Phagosome 1.75 7.11e-3 118/152 (77.63%) HLA-B;CLEC7A;HLA-F;...
Inflammatory bowel disease 1.75 7.90e-3 58/65 (89.23%) IL1B;MAF;HLA-DQA1;...
RIG-I-like receptor signaling pathway 1.72 9.00e-3 64/70 (91.43%) ISG15;CASP8;CXCL8;...
Thyroid hormone signaling pathway -1.61 3.92e-2 112/121 (92.56%) MED27;ATP1A1;RCAN2;...
Rap1 signaling pathway -1.61 3.83e-2 184/210 (87.62%) MAP2K6;FGFR1;ADCY1;...
Glucagon signaling pathway -1.61 3.95e-2 89/107 (83.18%) CALML5;PCK1;PRMT1;...
Axon guidance -1.62 3.87e-2 151/182 (82.97%) CDC42;RAC3;PPP3CB;...
Mucin type O-glycan biosynthesis -1.64 3.60e-2 20/36 (55.56%) ST3GAL1;GALNT10;GALNT2;...
Glutamatergic synapse -1.64 3.74e-2 97/114 (85.09%) PLD1;ADCY1;GNG12;...
Vasopressin-regulated water reabsorption -1.64 3.77e-2 40/44 (90.91%) DYNC1H1;ARHGDIB;PRKACB;...
Platelet activation -1.64 3.89e-2 106/124 (85.48%) ADCY1;RAP1A;TLN1;...
Gap junction -1.66 3.56e-2 72/88 (81.82%) ADCY1;GNAI3;MAPK1;...
Cholinergic synapse -1.66 3.73e-2 99/113 (87.61%) JAK2;ADCY1;CHRM3;...
Amphetamine addiction -1.66 3.86e-2 57/69 (82.61%) PDYN;CACNA1D;PPP3CB;...
Selenocompound metabolism -1.67 3.59e-2 11/17 (64.71%) CTH;MTR;SEPHS1;...
GnRH signaling pathway -1.69 3.34e-2 80/93 (86.02%) SOS2;RAF1;ITPR1;...
Aldosterone synthesis and secretion -1.69 3.48e-2 85/98 (86.73%) AGTR1;AGT;ITPR1;...
Thyroid hormone synthesis -1.69 3.64e-2 66/75 (88%) TTF2;ITPR1;CANX;...
Progesterone-mediated oocyte maturation -1.69 3.75e-2 75/100 (75%) CPEB3;STK10;PIK3R1;...
Protein processing in endoplasmic reticulum -1.70 3.94e-2 127/171 (74.27%) PDIA4;GANAB;SSR2;...
Circadian entrainment -1.71 3.86e-2 85/97 (87.63%) ADCY1;GNG12;CACNA1D;...
Regulation of actin cytoskeleton -1.72 3.93e-2 185/218 (84.86%) ITGA1;ARPC2;GNA12;...
Propanoate metabolism -1.75 3.01e-2 30/34 (88.24%) MLYCD;BCKDHA;ACOX3;...
Vascular smooth muscle contraction -1.75 3.11e-2 113/133 (84.96%) PRKCH;PPP1CB;RAF1;...
Salivary secretion -1.78 3.34e-2 76/93 (81.72%) AQP5;ADCY1;CHRM3;...
Gastric acid secretion -1.78 3.51e-2 63/76 (82.89%) ADCY1;CCKBR;CHRM3;...
Oocyte meiosis -1.78 3.87e-2 90/129 (69.77%) PPP2R5A;ADCY1;PPP3CB;...
Cortisol synthesis and secretion -1.81 3.51e-2 58/65 (89.23%) AGTR1;AGT;ITPR1;...
Adherens junction -1.86 1.81e-2 63/71 (88.73%) TJP1;SRC;SORBS1;...
Focal adhesion -1.87 1.76e-2 180/201 (89.55%) ITGA2;FLNB;TLN2;...
Melanogenesis -1.88 2.01e-2 74/101 (73.27%) TCF7L2;LEF1;ADCY1;...
Dopaminergic synapse -1.90 5.02e-3 115/132 (87.12%) ITPR1;MAPK9;PPP2R3A;...
Long-term potentiation -1.99 1.00e-2 61/67 (91.04%) ADCY1;RAP1A;BRAF;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 3.33uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 3.33uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 3.33uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 3.33uM 24H