Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIYDT4)

Drug Name
Cabozantinib Drug Info
Synonyms Cabometyx; Cometriq
Cross-matching ID
PubChem CID
25102847
ChEBI ID
CHEMBL2105717
CAS Number
CAS 849217-68-1
TTD Drug ID
D0IQ6P
INTEDE Drug ID
DR0254
ACDINA Drug ID
D00087

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.43 0.00e+0 34/36 (94.44%) MCM5;PRIM1;MCM6;...
Steroid biosynthesis 2.30 0.00e+0 19/20 (95%) MSMO1;SQLE;FDFT1;...
Butanoate metabolism 2.03 0.00e+0 23/28 (82.14%) HMGCS1;ACAT2;HADH;...
Fanconi anemia pathway 2.02 0.00e+0 36/54 (66.67%) RPA3;FANCI;RMI1;...
Base excision repair 1.95 1.49e-3 29/33 (87.88%) APEX1;POLE2;FEN1;...
Valine, leucine and isoleucine degradation 1.95 1.24e-3 42/48 (87.5%) HMGCS1;ACAT2;HADH;...
Mismatch repair 1.91 3.19e-3 22/23 (95.65%) RPA3;PCNA;RFC4;...
Asthma 1.89 5.59e-3 25/31 (80.65%) CD40;HLA-DRA;HLA-DRB1;...
Autoimmune thyroid disease 1.85 6.62e-3 46/53 (86.79%) CD40;HLA-DRA;HLA-DRB1;...
alpha-Linolenic acid metabolism 1.84 6.71e-3 17/25 (68%) FADS2;PLA2G4A;PLAAT3
Terpenoid backbone biosynthesis 1.83 7.45e-3 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
Glyoxylate and dicarboxylate metabolism 1.82 6.83e-3 23/30 (76.67%) ACAT2;CAT;SHMT1;...
Allograft rejection 1.80 1.09e-2 32/38 (84.21%) CD40;HLA-DRA;HLA-DRB1;...
Homologous recombination 1.79 1.12e-2 35/41 (85.37%) RPA3;RBBP8;BRCA1;...
Biosynthesis of unsaturated fatty acids 1.79 1.09e-2 21/27 (77.78%) SCD;FADS2;FADS1;...
Propanoate metabolism 1.75 1.49e-2 30/34 (88.24%) ACAT2;EHHADH;ACACB;...
Tryptophan metabolism 1.73 1.75e-2 35/42 (83.33%) ACAT2;HADH;KMO;...
Systemic lupus erythematosus 1.69 2.19e-2 45/135 (33.33%) CD40;HLA-DRA;C1S;...
Cell cycle 1.66 2.74e-2 110/124 (88.71%) MCM5;ESPL1;SKP2;...
Ascorbate and aldarate metabolism 1.65 2.72e-2 15/30 (50%) ALDH1B1;ALDH2;UGT2B17;...
Lysine degradation 1.62 3.55e-2 51/63 (80.95%) ACAT2;HADH;SMYD3;...
Glutathione metabolism 1.61 3.62e-2 43/57 (75.44%) GSTA1;CHAC1;IDH1;...
Sulfur relay system 1.60 4.08e-2 5/8 (62.5%) TST;MPST
PPAR signaling pathway 1.59 4.00e-2 66/74 (89.19%) HMGCS1;SCD;FADS2;...
AGE-RAGE signaling pathway in diabetic complications -1.61 4.50e-2 97/100 (97%) HRAS;MAPK8;STAT3;...
Kaposi sarcoma-associated herpesvirus infection -1.61 4.66e-2 172/193 (89.12%) RAC1;GNG3;MAP2K2;...
NOD-like receptor signaling pathway -1.61 4.84e-2 145/181 (80.11%) CTSB;VDAC2;PLCB3;...
Pathogenic Escherichia coli infection -1.62 4.78e-2 152/197 (77.16%) CLDN17;CLDN1;RAC1;...
Yersinia infection -1.64 4.15e-2 120/137 (87.59%) IL18;ARF6;CD8B;...
Adherens junction -1.64 4.21e-2 63/71 (88.73%) CTNND1;PTPRM;TCF7;...
Endocytosis -1.64 4.34e-2 198/252 (78.57%) HLA-A;RAB31;ARPC5;...
GABAergic synapse -1.65 4.25e-2 76/89 (85.39%) GNAI3;GNG3;GNB1;...
Rheumatoid arthritis -1.66 4.21e-2 78/93 (83.87%) ATP6V1F;ATP6AP1;IL15;...
Chagas disease -1.67 3.46e-2 93/102 (91.18%) GNAI3;CD3G;CD247;...
Oxytocin signaling pathway -1.67 3.57e-2 128/154 (83.12%) PRKAB2;NRAS;KCNJ2;...
Osteoclast differentiation -1.69 2.70e-2 117/127 (92.13%) SQSTM1;CSF1;FOS;...
NF-kappa B signaling pathway -1.69 2.86e-2 90/104 (86.54%) ERC1;TRAF1;CYLD;...
Adrenergic signaling in cardiomyocytes -1.70 2.80e-2 130/150 (86.67%) CAMK2G;CACNA2D2;TNNT2;...
Mineral absorption -1.70 2.82e-2 48/60 (80%) ATP2B1;ATP1B2;ATP2B4;...
Shigellosis -1.71 2.83e-2 180/246 (73.17%) GSK3B;MAPK8;ITPR1;...
Pancreatic cancer -1.71 2.95e-2 75/76 (98.68%) RAC2;MAPK8;STAT3;...
Arrhythmogenic right ventricular cardiomyopathy -1.72 2.45e-2 70/77 (90.91%) CTNNA2;DSC2;DMD;...
Colorectal cancer -1.72 2.56e-2 84/86 (97.67%) APPL1;BRAF;NRAS;...
Salmonella infection -1.74 2.30e-2 198/249 (79.52%) DCTN1;KLC2;RAC1;...
Vasopressin-regulated water reabsorption -1.75 2.42e-2 40/44 (90.91%) DYNC1LI1;CREB3L1;DYNLL1;...
Apelin signaling pathway -1.76 2.56e-2 117/137 (85.4%) GNAI3;GNG3;MAP2K2;...
Dilated cardiomyopathy -1.78 2.19e-2 86/96 (89.58%) MYH6;DMD;MYBPC3;...
Cardiac muscle contraction -1.78 2.56e-2 64/87 (73.56%) MYH6;COX5A;SLC9A7;...
TNF signaling pathway -1.79 3.07e-2 103/112 (91.96%) FAS;CSF1;IRF1;...
Hypertrophic cardiomyopathy -1.91 3.20e-3 81/90 (90%) MYH6;DMD;MYBPC3;...
Epithelial cell signaling in Helicobacter pylori infect... -1.98 0.00e+0 62/70 (88.57%) ATP6V1F;ATP6AP1;RAC1;...
Amoebiasis -2.08 0.00e+0 99/102 (97.06%) PRKACA;GNAQ;HSPB1;...
IL-17 signaling pathway -2.10 0.00e+0 84/94 (89.36%) CXCL6;TRAF3IP2;IL6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 30uM 24H
C4-2 CVCL_4782 Homo sapiens 1.25uM - 30uM 24H
DU 145 CVCL_0105 Homo sapiens 1.25uM - 30uM 24H
LNCaP CVCL_0395 Homo sapiens 1.25uM - 30uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 30uM 24H
VCaP CVCL_2235 Homo sapiens 1.25uM - 30uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H