Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIYHAW)

Drug Name
PU-H71 Drug Info
Synonyms
PU-H71; 873436-91-0; PU H71; PU-H 71; UNII-06IVK87M04; CHEMBL200102; 06IVK87M04; 6-amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-n-(1-methylethyl)-9h-purine-9-propanamine; NSC 750424; 8-[(6-Iodo-1,3-Benzodioxol-5-Yl)thio]-9-[3-(Isopropylamino)propyl]-9h-Purin-6-Amine; 8-(6-Iodobenzo[d][1,3]dioxol-5-ylthio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine; 8-((6-Iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine; H71; PUH-71; 2fwz; PU-H-71
Cross-matching ID
PubChem CID
9549213
ChEBI ID
CHEMBL200102
CAS Number
CAS 873436-91-0
TTD Drug ID
D01FYA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.60 0.00e+0 127/171 (74.27%) HSPA1A;HSPA8;DNAJB1;...
Spliceosome 2.21 0.00e+0 101/150 (67.33%) HSPA1A;HSPA8;HSPA6;...
Proteasome 1.90 1.96e-2 44/46 (95.65%) PSMD1;IFNG;PSMC2;...
Antigen processing and presentation 1.82 3.11e-2 60/78 (76.92%) HSPA1A;HSPA8;HSPA6;...
Protein export 1.80 3.40e-2 17/23 (73.91%) HSPA5;SEC63;SRP54;...
Prion disease 1.79 3.05e-2 209/273 (76.56%) HSPA1A;HSPA8;HSPA6;...
Estrogen signaling pathway 1.77 2.90e-2 119/137 (86.86%) HSPA1A;HSPA8;HSPA6;...
p53 signaling pathway -1.68 4.63e-2 63/73 (86.3%) PMAIP1;SIAH1;DDB2;...
Hepatitis C -1.69 4.58e-2 139/157 (88.54%) CLDN17;E2F3;BAX;...
Bladder cancer -1.69 4.97e-2 40/41 (97.56%) CDK4;RPS6KA5;E2F3;...
AGE-RAGE signaling pathway in diabetic complications -1.70 4.83e-2 97/100 (97%) DIAPH1;CASP3;STAT3;...
Colorectal cancer -1.80 1.68e-2 84/86 (97.67%) TCF7;SOS2;AKT1;...
Leishmaniasis -1.85 7.20e-3 67/77 (87.01%) IRAK1;C3;HLA-DOB;...
Kaposi sarcoma-associated herpesvirus infection -1.93 4.86e-3 172/193 (89.12%) HLA-G;CASP3;STAT3;...
Cytosolic DNA-sensing pathway -1.94 3.70e-3 52/63 (82.54%) NFKBIB;DDX58;RIPK1;...
RIG-I-like receptor signaling pathway -1.95 2.16e-3 64/70 (91.43%) NFKBIB;DDX58;RIPK1;...
IL-17 signaling pathway -1.96 2.59e-3 84/94 (89.36%) TRAF3;MAPK9;MUC5B;...
C-type lectin receptor signaling pathway -1.96 3.24e-3 93/104 (89.42%) AKT1;IL1B;HRAS;...
Malaria -1.97 4.32e-3 44/50 (88%) SDC1;SDC2;MET;...
NF-kappa B signaling pathway -2.11 0.00e+0 90/104 (86.54%) CCL21;DDX58;RIPK1;...
TNF signaling pathway -2.28 0.00e+0 103/112 (91.96%) AKT1;RIPK1;IL1B;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H