Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJ13KI)

• Drug Name: Terconazole Drug Info
• Synonyms: Fungistat; Terazol; Terconazol; Terconazolum; Tercospor; Triaconazole; Zazole; R 42470; Terazol 3; Terazol 7; Terazol 73; Tetrazol 3; Tetrazol 7; Gyno-Terazol; R 42,470; R-42470; Terazol 3 (TN); Terazol 7 & 3; Terazol Cream & Suppositories; Terconazol [INN-Spanish]; Terconazolum [INN-Latin]; Terconazole (USAN/INN); Terconazole [USAN:INN:BAN]; Cis-1-(p-((2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-4-isopropylpiperazine; Piperazine, 1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-, rel-(2R,4S); 1-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-4-(1-methylethyl)piperazine; 1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-ylpiperazine; 1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-ylpiperazine; 1-[4-[[(4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-ylpiperazine; 1-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-ylpiperazine
• Therapeutic Class: Antifungal Agents
• Cross-matching ID:
  PubChem CID: 441383
  ChEBI ID: CHEMBL82980
  CAS Number: CAS 67915-31-5
  TTD Drug ID: D01AQT
  ACDINA Drug ID: D01477

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.56	0.00e+0	19/20 (95%)	SQLE;MSMO1;DHCR7;...
Malaria	2.17	0.00e+0	44/50 (88%)	THBS2;VCAM1;CXCL8;...
Terpenoid backbone biosynthesis	2.12	0.00e+0	18/22 (81.82%)	HMGCS1;IDI1;FDPS;...
Viral protein interaction with cytokine and cytokine re...	2.07	0.00e+0	84/100 (84%)	CXCL14;CXCL8;CXCR4;...
PPAR signaling pathway	2.02	0.00e+0	66/74 (89.19%)	HMGCS1;FADS2;SCD;...
Phagosome	2.02	0.00e+0	118/152 (77.63%)	THBS2;ATP6V0E2;FCGR3B;...
Biosynthesis of unsaturated fatty acids	1.91	7.95e-3	21/27 (77.78%)	FADS2;SCD;FADS1;...
Cholesterol metabolism	1.89	9.74e-3	44/50 (88%)	LIPG;SOAT1;SCARB1;...
NF-kappa B signaling pathway	1.87	1.36e-2	90/104 (86.54%)	VCAM1;CXCL8;CCL19;...
Rheumatoid arthritis	1.85	1.45e-2	78/93 (83.87%)	ATP6V0E2;CXCL8;CTSK;...
IL-17 signaling pathway	1.84	1.62e-2	84/94 (89.36%)	LCN2;CXCL8;JUND;...
Chemokine signaling pathway	1.81	1.67e-2	163/192 (84.9%)	CXCL14;CXCL8;CXCR4;...
Complement and coagulation cascades	1.80	1.71e-2	76/85 (89.41%)	SERPINA1;CFB;F2R;...
Regulation of lipolysis in adipocytes	1.78	2.31e-2	52/55 (94.55%)	NPY1R;IRS2;GNAS;...
Synthesis and degradation of ketone bodies	1.77	2.67e-2	9/10 (90%)	HMGCS1;ACAT2

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	6H, 24H	Show ▼