Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJ18YL)

Drug Name
Secnidazole Drug Info
Synonyms
3366-95-8; Secnidazol; Secnidazolum; Flagentyl; Secnidazolum [INN-Latin]; Solosec; RP 14539; Secnidazol [INN-Spanish]; PM 185184;Secnidazole (Flagentyl); SYM-1219; EINECS 222-134-0; seknidazol; MLS000559043; PM-185184; NCGC00095158-01; SMR000149359; RP-14539
Cross-matching ID
PubChem CID
71815
ChEBI ID
CHEMBL94433
CAS Number
CAS 3366-95-8
TTD Drug ID
D0V5IW
INTEDE Drug ID
DR2431
ACDINA Drug ID
D01418

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
N-Glycan biosynthesis 1.86 7.84e-2 38/50 (76%) ALG6;GANAB;ALG5;...
T cell receptor signaling pathway 1.78 7.84e-2 93/104 (89.42%) CDC42;ITK;ZAP70;...
Th17 cell differentiation 1.70 1.34e-1 95/107 (88.79%) IL6ST;TGFBR2;IL27RA;...
Various types of N-glycan biosynthesis 1.67 1.46e-1 26/39 (66.67%) B4GALT1;MAN1C1;DDOST;...
Glutathione metabolism 1.64 1.73e-1 43/57 (75.44%) GPX2;PGD;GPX3;...
Vitamin digestion and absorption 1.64 1.51e-1 17/24 (70.83%) ABCC1;SLC5A6;APOA1;...
Neutrophil extracellular trap formation 1.57 2.42e-1 101/189 (53.44%) CLCN3;HAT1;FPR1;...
Biosynthesis of unsaturated fatty acids 1.54 2.79e-1 21/27 (77.78%) HACD1;ELOVL5;SCD5;...
Other glycan degradation 1.53 2.81e-1 13/18 (72.22%) FUCA1;GLB1;NEU1;...
beta-Alanine metabolism 1.52 2.71e-1 25/30 (83.33%) ALDH3A1;ALDH3A2;DPYD;...
Natural killer cell mediated cytotoxicity 1.51 2.71e-1 99/131 (75.57%) PRKCA;CD48;TNFSF10;...
Apoptosis 1.49 2.96e-1 126/168 (75%) CASP10;CTSB;CYCS;...
Pathogenic Escherichia coli infection 1.48 2.84e-1 152/197 (77.16%) CYCS;CDC42;F2R;...
Chagas disease 1.48 2.67e-1 93/102 (91.18%) GNAS;TGFBR2;CFLAR;...
Galactose metabolism 1.47 2.70e-1 26/31 (83.87%) GLB1;B4GALT1;AKR1B10;...
Other types of O-glycan biosynthesis 1.45 2.98e-1 29/47 (61.7%) GALNT12;GALNT1;MFNG;...
Steroid biosynthesis 1.45 3.04e-1 19/20 (95%) MSMO1;CYP24A1;CYP51A1;...
Human immunodeficiency virus 1 infection 1.44 2.95e-1 189/212 (89.15%) CRK;CYCS;PRKCA;...
Yersinia infection 1.43 2.97e-1 120/137 (87.59%) CRK;CDC42;SRC;...
Dopaminergic synapse 1.42 3.07e-1 115/132 (87.12%) GNAS;PRKCA;GNG11;...
Mismatch repair 1.39 3.65e-1 22/23 (95.65%) RFC2;PCNA;RFC4;...
VEGF signaling pathway 1.39 3.53e-1 50/59 (84.75%) CDC42;PRKCA;SRC;...
Fc gamma R-mediated phagocytosis 1.38 3.61e-1 79/97 (81.44%) CRK;CDC42;PRKCA;...
PD-L1 expression and PD-1 checkpoint pathway in cancer 1.37 3.72e-1 79/89 (88.76%) ZAP70;CD3E;CD247;...
Terpenoid backbone biosynthesis 1.36 3.80e-1 18/22 (81.82%) PCYOX1;GGPS1;PDSS1;...
Phosphonate and phosphinate metabolism 1.34 4.02e-1 5/6 (83.33%) CHPT1
Pentose phosphate pathway 1.32 4.41e-1 25/30 (83.33%) PGD;TALDO1;TKT;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.31 4.40e-1 9/11 (81.82%) NQO1;COQ2
Bacterial invasion of epithelial cells 1.30 4.45e-1 59/77 (76.62%) CRK;CDC42;SRC;...
Hepatitis B 1.30 4.45e-1 151/162 (93.21%) CASP10;TGFBR2;IKBKE;...
Inositol phosphate metabolism -1.22 6.58e-1 66/73 (90.41%) PIK3CG;INPP1;PLCE1;...
Human papillomavirus infection -1.22 6.62e-1 284/331 (85.8%) BCAP31;ITGA8;ATP6V1A;...
Sulfur metabolism -1.23 6.73e-1 9/10 (90%) SELENBP1;TST;SQOR;...
Pertussis -1.23 6.84e-1 64/76 (84.21%) CXCL6;C4BPB;PYCARD;...
Rheumatoid arthritis -1.25 6.93e-1 78/93 (83.87%) ATP6V1A;CXCL6;TGFB3;...
Melanoma -1.28 6.17e-1 68/72 (94.44%) GADD45A;E2F2;FGF2;...
Glioma -1.29 5.89e-1 67/75 (89.33%) GADD45A;E2F2;SHC1;...
Glucagon signaling pathway -1.30 5.81e-1 89/107 (83.18%) PRKAG2;PFKM;LDHB;...
Autoimmune thyroid disease -1.30 6.01e-1 46/53 (86.79%) HLA-DQA1;CD40;CGA
Amoebiasis -1.32 5.65e-1 99/102 (97.06%) COL4A1;MUC2;LAMC2;...
Bladder cancer -1.32 5.83e-1 40/41 (97.56%) CCND1;TYMP;RPS6KA5;...
alpha-Linolenic acid metabolism -1.33 5.76e-1 17/25 (68%) PLA2G4A;FADS2;PLA2G4C;...
Arginine biosynthesis -1.33 6.01e-1 17/22 (77.27%) GLS2;GLUD1;CPS1;...
Linoleic acid metabolism -1.36 5.38e-1 21/29 (72.41%) CYP3A4;PLA2G4A;CYP2C8;...
Bile secretion -1.37 5.24e-1 68/90 (75.56%) UGT2B28;ABCG2;ABCB4;...
Retinol metabolism -1.37 5.37e-1 41/68 (60.29%) ADH6;PNPLA4;CYP2C18;...
Ovarian steroidogenesis -1.38 5.35e-1 41/51 (80.39%) ADCY9;ADCY8;INSR;...
Proximal tubule bicarbonate reclamation -1.40 4.97e-1 21/23 (91.3%) PCK2;GLUD2;ATP1A3;...
Estrogen signaling pathway -1.42 4.96e-1 119/137 (86.86%) CREB1;HSPA6;GABBR1;...
SNARE interactions in vesicular transport -1.45 4.30e-1 19/33 (57.58%) STX16;STX7;STX3;...
D-Glutamine and D-glutamate metabolism -1.46 4.37e-1 5/5 (100%) GLUD2;GLS2;GLUD1;...
Nicotinate and nicotinamide metabolism -1.47 4.53e-1 25/35 (71.43%) NMNAT2;SIRT7;NT5C2;...
Regulation of lipolysis in adipocytes -1.51 3.57e-1 52/55 (94.55%) ADCY9;ADCY8;ADORA1;...
ABC transporters -1.52 3.43e-1 37/45 (82.22%) ABCD4;ABCA7;ABCB11;...
Phototransduction -1.58 2.58e-1 21/29 (72.41%) CALML4;CALML3;CALML5
Ether lipid metabolism -1.60 2.40e-1 32/49 (65.31%) GDPD3;PLA2G4A;PLA2G4C;...
ECM-receptor interaction -1.64 2.20e-1 80/88 (90.91%) ITGB5;CHAD;COL4A1;...
Mineral absorption -1.68 1.69e-1 48/60 (80%) SLC34A2;MT1M;VDR;...
Protein digestion and absorption -1.69 2.36e-1 78/103 (75.73%) MME;COL2A1;COL7A1;...
Steroid hormone biosynthesis -1.73 3.38e-1 43/61 (70.49%) STS;CYP3A4;CYP21A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 3.33uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 20uM 72H
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 3.33uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H