Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJ1DIB)

Drug Name
S-tenatoprazole Drug Info
Synonyms Benatoprazole; Protop; Tenatoprazole; Ulsacare; STU-199; STU-Na; TU-199; S-tenatoprazole-Na
Cross-matching ID
PubChem CID
11552393
TTD Drug ID
D0N1PZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Arginine and proline metabolism -1.75 3.67e-2 39/50 (78%) NOS2;AMD1;SMS;...
Aldosterone-regulated sodium reabsorption -1.75 4.13e-2 34/37 (91.89%) ATP1B3;NEDD4L;INSR;...
Steroid biosynthesis -1.77 3.33e-2 19/20 (95%) SOAT1;NSDHL;DHCR7;...
Cardiac muscle contraction -1.78 3.08e-2 64/87 (73.56%) ATP2A1;CACNG2;ATP1A3;...
Dilated cardiomyopathy -1.78 3.69e-2 86/96 (89.58%) CACNB2;MYL2;ITGB5;...
Pyruvate metabolism -1.84 2.92e-2 41/47 (87.23%) DLAT;PDHB;GRHPR;...
Citrate cycle (TCA cycle) -1.86 2.92e-2 30/30 (100%) IDH3B;SDHA;DLAT;...
Type II diabetes mellitus -1.92 1.94e-2 42/46 (91.3%) IRS2;INSR;ADIPOQ;...
Propanoate metabolism -1.95 1.94e-2 30/34 (88.24%) ABAT;ALDH6A1;ECHDC1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H