Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJ46CB)

Drug Name
Buthionine sulfoximine Drug Info
Synonyms AC1MS6SH
Cross-matching ID
PubChem CID
21157
ChEBI ID
CHEMBL1256575
CAS Number
CAS 5072-26-4
TTD Drug ID
D0Z6VR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Base excision repair 2.23 0.00e+0 29/33 (87.88%) PARP2;NTHL1;NEIL3;...
Ribosome biogenesis in eukaryotes 2.01 1.07e-2 52/108 (48.15%) EIF6;DKC1;TBL3;...
Pyrimidine metabolism 1.99 7.10e-3 40/56 (71.43%) ENTPD1;CAD;TYMP;...
DNA replication 1.98 5.33e-3 34/36 (94.44%) POLD1;POLE2;MCM6;...
Drug metabolism 1.86 1.42e-2 78/151 (51.66%) CYP2C8;CYP3A4;CYP2C9;...
Linoleic acid metabolism 1.75 3.67e-2 21/29 (72.41%) CYP2C8;CYP3A4;CYP2C9;...
SNARE interactions in vesicular transport -1.68 4.80e-2 19/33 (57.58%) SNAP29;STX6;STX1A;...
Epithelial cell signaling in Helicobacter pylori infect... -1.69 4.95e-2 62/70 (88.57%) PLCG1;MAPK10;EGFR;...
Ferroptosis -1.70 3.94e-2 36/41 (87.8%) MAP1LC3C;ATG5;CYBB;...
Protein processing in endoplasmic reticulum -1.70 3.89e-2 127/171 (74.27%) BAX;SEC61A2;CUL1;...
Tryptophan metabolism -1.72 3.76e-2 35/42 (83.33%) MAOB;ACAT1;ALDH7A1;...
Glyoxylate and dicarboxylate metabolism -1.72 3.86e-2 23/30 (76.67%) ACAT1;MDH1;ACO2;...
Lysosome -1.73 3.89e-2 115/128 (89.84%) HYAL3;AP3B2;CD164;...
Mitophagy -1.76 3.40e-2 56/68 (82.35%) NBR1;MAPK9;MRAS;...
Citrate cycle (TCA cycle) -1.76 3.51e-2 30/30 (100%) IDH1;ACO1;IDH2;...
Synaptic vesicle cycle -1.76 3.89e-2 63/78 (80.77%) STX3;DNM2;ATP6V0A2;...
Rheumatoid arthritis -1.76 4.38e-2 78/93 (83.87%) HLA-DPB1;HLA-DPA1;ATP6V0A2;...
Pyruvate metabolism -1.80 2.50e-2 41/47 (87.23%) ME2;PCK2;PC;...
Fatty acid elongation -1.81 2.53e-2 19/27 (70.37%) TECR;ELOVL4;HACD1;...
Propanoate metabolism -1.81 2.57e-2 30/34 (88.24%) DBT;SUCLA2;ACAT1;...
Steroid biosynthesis -1.96 0.00e+0 19/20 (95%) CYP27B1;TM7SF2;SQLE;...
Collecting duct acid secretion -2.00 0.00e+0 22/27 (81.48%) ATP6V0A2;ATP6V1B1;ATP6V1F;...
Vibrio cholerae infection -2.09 0.00e+0 44/50 (88%) ATP6V0A2;ATP6V1B1;KCNQ1;...
Valine, leucine and isoleucine degradation -2.15 0.00e+0 42/48 (87.5%) IVD;ALDH3A2;ACAA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.002uM - 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.002uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H