Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJ7A0H)

• Drug Name: Cefdinir Drug Info
• Synonyms: CFDN; Cefdinirum; Cefdinyl; Cefdirnir; Cefzon; Omnicef; BMY 28488; FK 482; PD 134393; Cefdinir [USAN:INN]; Cefdinirum [INN-Latin]; Cefzon (TN); FK-482; FR-80482; KS-1038; Omnicef (TN); PD-134393; Cefdinir (JP15/USAN/INN); Omnicef, FK-482, BMY-28488, PD 134393, CI-983, Cefdinir; (-)-(6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7(sup 2)-(Z)-oxime; (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetyl]amino}-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-(2 (2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid; 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetamido]-3-ethenyl-3,4-didehydrocepham-4-carboxylic acid
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 6915944
  ChEBI ID: CHEMBL927
  CAS Number: CAS 91832-40-5
  TTD Drug ID: D0WS1X
  VARIDT Drug ID: DR00692
  ACDINA Drug ID: D00106

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Prion disease	-1.70	4.82e-2	209/273 (76.56%)	PSMA6;NDUFA1;CSNK2A2;...
Collecting duct acid secretion	-1.70	5.00e-2	22/27 (81.48%)	ATP6V0E1;ATP6V0A1;CA2;...
Diabetic cardiomyopathy	-1.78	2.65e-2	162/203 (79.8%)	NDUFA1;RYR2;PRKCB;...
IL-17 signaling pathway	-1.82	1.74e-2	84/94 (89.36%)	MMP13;FOS;CXCL10;...
Metabolism of xenobiotics by cytochrome P450	-1.86	7.64e-3	49/77 (63.64%)	CYP2E1;CYP2F1;CBR1;...
Rheumatoid arthritis	-1.88	2.83e-3	78/93 (83.87%)	LTB;CXCL6;IL15;...
Pentose and glucuronate interconversions	-1.89	3.18e-3	17/34 (50%)	UGT2B28;UGT2B15;AKR1A1;...
RNA polymerase	-1.91	3.64e-3	23/31 (74.19%)	POLR2F;POLR1D;POLR2K;...
Fructose and mannose metabolism	-1.94	4.25e-3	30/33 (90.91%)	ALDOC;FBP2;SORD;...
Non-alcoholic fatty liver disease	-1.94	5.09e-3	126/155 (81.29%)	COX6A2;COX8A;NDUFA10;...
Arginine biosynthesis	-1.96	6.37e-3	17/22 (77.27%)	GLS;GOT1;ASL;...
Mineral absorption	-2.01	0.00e+0	48/60 (80%)	ATP2B1;HMOX2;HEPH;...
Ribosome	-2.08	0.00e+0	113/158 (71.52%)	MRPS15;RPS23;RPS11;...
Oxidative phosphorylation	-2.38	0.00e+0	93/133 (69.92%)	ATP5PO;COX6A2;COX8A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼