Details of the Drug Pharmacogenomic Perturbation Atlas

Dexfenfluramine Drug Info

DEXFENFLURAN; Dexfenfluramine (INN); Redux (TN); (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine; (S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine

Therapeutic Class

Appetite Depressants

Cross-matching ID

PubChem CID

66265

ChEBI ID

CHEMBL248702

CAS Number

CAS 3239-44-9

TTD Drug ID

D0F9SG

INTEDE Drug ID

DR0466

General Information of Drug (ID: DMJ7YDS)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.03	0.00e+0	19/20 (95%)	MSMO1;DHCR7;CYP24A1;...
GnRH secretion	1.95	7.19e-3	60/64 (93.75%)	SPP1;ITPR1;PRKCA;...
Neutrophil extracellular trap formation	1.88	1.44e-2	101/189 (53.44%)	SRC;ITGB3;HAT1;...
Thiamine metabolism	1.85	1.08e-2	12/15 (80%)	AK4;AK2;ACP1;...
Gastric acid secretion	1.82	1.15e-2	63/76 (82.89%)	ITPR1;MYLK;PRKCA;...
Platelet activation	1.82	9.59e-3	106/124 (85.48%)	SRC;ITGB3;ITPR1;...
Epithelial cell signaling in Helicobacter pylori infect...	1.81	1.03e-2	62/70 (88.57%)	SRC;PAK1;ATP6V0E2;...
Antigen processing and presentation	1.73	2.88e-2	60/78 (76.92%)	HSPA8;HLA-DOB;NFYA;...
Chemokine signaling pathway	1.72	3.36e-2	163/192 (84.9%)	SRC;PAK1;CCR7;...
Human immunodeficiency virus 1 infection	1.71	3.16e-2	189/212 (89.15%)	PAK1;ITPR1;APOBEC3B;...
Insulin secretion	1.70	3.79e-2	75/86 (87.21%)	PRKCA;KCNMB1;SNAP25;...
Cholinergic synapse	1.69	4.43e-2	99/113 (87.61%)	ITPR1;PRKCA;KCNJ2;...
Adherens junction	1.66	4.89e-2	63/71 (88.73%)	SRC;TGFBR2;LEF1;...
Cortisol synthesis and secretion	1.64	5.00e-2	58/65 (89.23%)	ITPR1;PBX1;GNA11;...
Fluid shear stress and atherosclerosis	1.64	4.82e-2	123/139 (88.49%)	SRC;ITGB3;MAP3K5;...
Lysine degradation	1.63	4.93e-2	51/63 (80.95%)	DHTKD1;PLOD2;BBOX1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H