Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJ90O5)

• Drug Name: Medrysone Drug Info
• Synonyms: Hydroxymesterone; Medrifar; Medritonic; Medrocort; Visudrisone; Medrysone (USAN); U-8471; (6S,8S,9S,10R,11S,13S,14S,17S)-17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one; 11.beta.-Hydroxy-6.alpha.-methylpregn-4-ene-3,20-dione; 11.beta.-Hydroxy-6.alpha.-methylprogesterone; 11beta-Hydroxy-6alpha-methyl-4-pregnene-3,20-dione; 11beta-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione; 6.alpha.-Methyl-11.beta.-hydroxyprogesterone
• Cross-matching ID:
  PubChem CID: 247839
  ChEBI ID: CHEMBL34829
  CAS Number: CAS 2668-66-8
  TTD Drug ID: D04SFH
  INTEDE Drug ID: DR1013

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Tyrosine metabolism	1.99	0.00e+0	30/36 (83.33%)	MAOA;AOX1;ALDH3B1;...
Citrate cycle (TCA cycle)	1.97	0.00e+0	30/30 (100%)	DLD;CS;SDHA;...
Nicotinate and nicotinamide metabolism	1.88	5.17e-3	25/35 (71.43%)	NNMT;NAMPT;NMRK1;...
Non-alcoholic fatty liver disease	1.87	5.82e-3	126/155 (81.29%)	PRKAG2;ADIPOQ;IRS2;...
Phenylalanine metabolism	1.83	7.76e-3	14/17 (82.35%)	MAOA;ALDH3B1;AOC3;...
Aminoacyl-tRNA biosynthesis	1.72	4.14e-2	15/66 (22.73%)	IARS2;QRSL1;CARS2;...
RNA polymerase	1.71	3.99e-2	23/31 (74.19%)	POLR2I;POLR2L;POLR2E;...
DNA replication	1.71	3.49e-2	34/36 (94.44%)	RPA3;RFC5;MCM2;...
Fanconi anemia pathway	1.68	4.23e-2	36/54 (66.67%)	RAD51C;RPA3;RMI1;...
Oxidative phosphorylation	1.66	4.89e-2	93/133 (69.92%)	NDUFS8;ATP5MC3;NDUFB5;...
Salivary secretion	-1.82	4.86e-2	76/93 (81.72%)	ATP2B2;CHRM3;RYR3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼