Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJAS3O)

• Drug Name: Hydroxyamphetamine Drug Info
• Synonyms: Hydroxyamfetamine; Hydroxyamphetamide; Norpholedrine; Norveritol; Nov-Pholedrin; Oksamfetamin; Oxamfetamin; Oxamphetamine; Oxamphetaminium; Paradrine; Paredrine; Paredrinex; Pedrolon; Phenol, 4-(2-aminopropyl)-; Phenol, p-(2-aminopropyl)-; Phenol,4-(2-aminopropyl)-; Pulsoton; alpha-Methyltyramine; hydroxyamphetamine; p-(2-Aminopropyl)phenol; p-HYDROXYAMPHETAMINE; .alpha.-Methyltyramine; 1-p-Hydroxyphenyl-2-propylamine; 103-86-6; 2-Amino-1-(p-hydroxyphenyl)propane; 4-(2-Aminopropyl)phenol; 4-Hydroxyamphetamine
• Cross-matching ID:
  PubChem CID: 3651
  ChEBI ID: CHEMBL1546
  CAS Number: CAS 103-86-6
  INTEDE Drug ID: DR1770

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Pancreatic cancer	-1.67	4.74e-2	75/76 (98.68%)	RPS6KB1;AKT2;BAK1;...
Adherens junction	-1.68	4.62e-2	63/71 (88.73%)	SMAD4;EP300;WAS;...
B cell receptor signaling pathway	-1.69	4.39e-2	71/81 (87.65%)	MALT1;LILRB1;BCL10;...
Phagosome	-1.70	4.23e-2	118/152 (77.63%)	HLA-A;STX7;SEC61G;...
Endometrial cancer	-1.71	4.47e-2	56/58 (96.55%)	AKT2;BAK1;GADD45G;...
Hepatitis C	-1.72	4.52e-2	139/157 (88.54%)	CYCS;BAK1;CLDN9;...
Bladder cancer	-1.72	4.97e-2	40/41 (97.56%)	MDM2;MAP2K2;MAPK3;...
Osteoclast differentiation	-1.84	3.60e-2	117/127 (92.13%)	AKT2;FCGR2C;TNFRSF11A;...
Chronic myeloid leukemia	-1.85	4.36e-2	72/76 (94.74%)	AKT2;BAK1;GADD45G;...
Steroid biosynthesis	-1.93	2.62e-2	19/20 (95%)	SC5D;TM7SF2;CYP51A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲