Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJBW7X)

Drug Name
SEW2871 Drug Info
Synonyms SEW-2871; SEW 2871
Cross-matching ID
PubChem CID
4077460
ChEBI ID
CHEMBL92283
CAS Number
CAS 256414-75-2
TTD Drug ID
D0ZU0O

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Systemic lupus erythematosus 1.96 0.00e+0 45/135 (33.33%) C1QA;C7;CD40;...
Primary immunodeficiency 1.94 0.00e+0 33/38 (86.84%) BLNK;CD8A;LCK;...
Pyrimidine metabolism 1.92 0.00e+0 40/56 (71.43%) NME4;CDA;TYMP;...
DNA replication 1.89 2.25e-3 34/36 (94.44%) MCM6;MCM2;MCM5;...
Cell cycle 1.83 1.08e-2 110/124 (88.71%) ABL1;CCNB2;MCM6;...
Pentose phosphate pathway -1.79 1.87e-2 25/30 (83.33%) ALDOC;RPE;PFKM;...
Glycerophospholipid metabolism -1.82 1.59e-2 71/98 (72.45%) CHAT;PTDSS2;PGS1;...
Proximal tubule bicarbonate reclamation -1.82 1.51e-2 21/23 (91.3%) ATP1A2;MDH1;GLS;...
Bile secretion -1.87 3.14e-3 68/90 (75.56%) ADCY2;RXRA;SCARB1;...
Mineral absorption -1.97 0.00e+0 48/60 (80%) ATP7A;ATP2B2;ATP1A2;...
PPAR signaling pathway -1.98 0.00e+0 66/74 (89.19%) RXRA;ACOX1;UBC;...
Protein processing in endoplasmic reticulum -1.99 0.00e+0 127/171 (74.27%) STT3A;DNAJC3;SEC61A1;...
Cholesterol metabolism -2.13 0.00e+0 44/50 (88%) LIPC;ABCG5;CETP;...
Steroid biosynthesis -2.32 0.00e+0 19/20 (95%) HSD17B7;LSS;FDFT1;...
Ferroptosis -2.35 0.00e+0 36/41 (87.8%) CP;ACSL4;MAP1LC3B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H