Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJBXO3)

Drug Name
VX-661 Drug Info
Cross-matching ID
PubChem CID
46199646
ChEBI ID
CHEMBL3544914
CAS Number
CAS 1152311-62-0
TTD Drug ID
D0Z5HR
VARIDT Drug ID
DR01157
INTEDE Drug ID
DR1571

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.16 0.00e+0 19/20 (95%) SQLE;DHCR24;EBP;...
Lysosome 1.86 4.77e-2 115/128 (89.84%) LAPTM4B;ACP5;M6PR;...
Tryptophan metabolism 1.86 3.53e-2 35/42 (83.33%) KYNU;MAOA;DLD;...
Pentose phosphate pathway 1.85 2.65e-2 25/30 (83.33%) G6PD;PFKP;TKT;...
Glutathione metabolism 1.80 3.61e-2 43/57 (75.44%) GPX3;G6PD;GCLC;...
Steroid hormone biosynthesis -1.75 4.76e-2 43/61 (70.49%) HSD3B2;CYP11B2;HSD17B8;...
Proximal tubule bicarbonate reclamation -1.81 3.49e-2 21/23 (91.3%) MDH1;ATP1A2;ATP1B1;...
SNARE interactions in vesicular transport -1.83 4.76e-2 19/33 (57.58%) STX2;BET1L;BNIP1;...
Renin-angiotensin system -2.15 0.00e+0 20/23 (86.96%) CTSA;AGTR1;ENPEP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H