Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJC7NF)

• Drug Name: FERULIC ACID Drug Info
• Synonyms: ferulic acid; trans-Ferulic Acid; 1135-24-6; 4-Hydroxy-3-methoxycinnamic acid; 537-98-4; trans-4-Hydroxy-3-methoxycinnamic acid; 3-(4-Hydroxy-3-methoxyphenyl)acrylic acid; (E)-Ferulic acid; ferulate; Coniferic acid; Ferulic acid, trans-; (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid; 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid; Cinnamic acid, 4-hydroxy-3-methoxy-; 3-methoxy-4-hydroxycinnamic acid; (E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid; UNII-AVM951ZWST; Cinnamic acid, 4-hydroxy-3-methoxy-, (E)-
• Cross-matching ID:
  PubChem CID: 445858
  ChEBI ID: CHEMBL32749
  CAS Number: CAS 537-98-4
  TTD Drug ID: D03SLR
  INTEDE Drug ID: DR2602

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Vibrio cholerae infection	1.98	2.20e-2	44/50 (88%)	TJP1;ATP6V1B2;ATP6V1A;...
Autophagy	1.93	2.75e-2	113/169 (66.86%)	CTSD;GABARAPL1;DDIT4;...
SNARE interactions in vesicular transport	1.84	3.30e-2	19/33 (57.58%)	STX3;VAMP1;STX1A;...
Nitrogen metabolism	-1.76	4.40e-2	16/17 (94.12%)	CA7;CPS1;GLUD2;...
Purine metabolism	-1.78	4.58e-2	102/129 (79.07%)	PDE8B;PAICS;ENTPD1;...
Galactose metabolism	-1.85	2.44e-2	26/31 (83.87%)	B4GALT1;GLB1;PFKM;...
Pyrimidine metabolism	-1.86	3.21e-2	40/56 (71.43%)	CTPS1;DTYMK;RRM2;...
ECM-receptor interaction	-2.01	1.83e-2	80/88 (90.91%)	THBS1;ITGA3;ITGA4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲