Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJD34Q)

• Drug Name: (-)-eseroline Drug Info
• Synonyms: Eseroline; (-)-Eseroline; UNII-Q22H41O18D; CHEMBL310934; CHEBI:48845; C13H18N2O; HKGWQUVGHPDEBZ-OLZOCXBDSA-N; Q22H41O18D; (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol; 469-22-7; (3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol; Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, (3aS,8aR)-; (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-ol; Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, (3aS,8aR)-
• Cross-matching ID:
  PubChem CID: 119198
  ChEBI ID: CHEMBL48845
  CAS Number: CAS 469-22-7
  TTD Drug ID: D0D9RL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	2.48	0.00e+0	48/60 (80%)	MT1E;MT1X;MT1HL1;...
Proximal tubule bicarbonate reclamation	2.13	0.00e+0	21/23 (91.3%)	GLS;CA2;MDH1;...
Insulin secretion	2.02	3.41e-3	75/86 (87.21%)	STX1A;GNA11;CCK;...
Oxidative phosphorylation	2.01	2.56e-3	93/133 (69.92%)	ATP6V1D;ATP5MC3;COX6A1;...
Synaptic vesicle cycle	1.97	2.05e-3	63/78 (80.77%)	STX1A;SLC1A1;ATP6V1D;...
Amphetamine addiction	1.87	1.36e-2	57/69 (82.61%)	STX1A;FOSB;PRKACB;...
Glycolysis / Gluconeogenesis	1.87	1.17e-2	56/67 (83.58%)	DLD;PGK1;ALDH2;...
Riboflavin metabolism	1.84	1.66e-2	7/8 (87.5%)	BLVRB;RFK;ENPP1;...
Aldosterone-regulated sodium reabsorption	1.84	1.48e-2	34/37 (91.89%)	NR3C2;ATP1B1;ATP1B3;...
Arginine and proline metabolism	1.82	1.33e-2	39/50 (78%)	OAT;AOC1;GOT1;...
Collecting duct acid secretion	1.81	1.21e-2	22/27 (81.48%)	ATP6V1D;CA2;ATP6V0E1;...
Thyroid hormone synthesis	1.76	1.88e-2	66/75 (88%)	GPX3;PRKACB;ADCY9;...
Gastric acid secretion	1.71	3.23e-2	63/76 (82.89%)	EZR;PRKACB;CA2;...
Citrate cycle (TCA cycle)	1.70	3.22e-2	30/30 (100%)	DLD;MDH1;IDH3A;...
Cardiac muscle contraction	1.68	3.55e-2	64/87 (73.56%)	ATP1B1;ATP1B3;COX6A1;...
Aldosterone synthesis and secretion	1.64	4.80e-2	85/98 (86.73%)	GNA11;PRKACB;ADCY9;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼