Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJDVW4)

Drug Name
GSK2816126 Drug Info
Synonyms GSK 126; GSK-126
Cross-matching ID
PubChem CID
68210102
ChEBI ID
CHEMBL3287735
CAS Number
CAS 1346574-57-9
TTD Drug ID
D05FIJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.23 0.00e+0 34/36 (94.44%) POLE2;RPA3;FEN1;...
Cell cycle 2.06 0.00e+0 110/124 (88.71%) CDC20;CDK1;CDC7;...
Fanconi anemia pathway 2.03 2.23e-3 36/54 (66.67%) RPA3;USP1;RAD51;...
Mismatch repair 1.81 2.68e-2 22/23 (95.65%) RPA3;RFC3;RFC4;...
Nucleotide excision repair 1.74 4.96e-2 40/47 (85.11%) POLE2;RPA3;DDB2;...
ECM-receptor interaction -1.76 3.19e-2 80/88 (90.91%) ITGB4;THBS3;DAG1;...
Th1 and Th2 cell differentiation -1.78 2.78e-2 80/92 (86.96%) STAT6;NFKBIB;IL12RB2;...
Synaptic vesicle cycle -1.80 2.43e-2 63/78 (80.77%) ATP6V0A1;SLC18A2;ATP6V1B2;...
Viral myocarditis -1.82 2.38e-2 53/60 (88.33%) ACTB;HLA-DQA1;HLA-E;...
Type I diabetes mellitus -1.85 2.31e-2 38/43 (88.37%) HLA-DQA1;HLA-E;HLA-G;...
Allograft rejection -1.87 2.22e-2 32/38 (84.21%) HLA-DQA1;HLA-E;HLA-G;...
Graft-versus-host disease -1.89 1.73e-2 32/42 (76.19%) HLA-DQA1;HLA-E;HLA-G;...
Phagosome -1.98 4.63e-3 118/152 (77.63%) HLA-DOA;ATP6V1B2;THBS3;...
Other glycan degradation -2.14 0.00e+0 13/18 (72.22%) GLB1;MANBA;MAN2B2;...
Lysosome -2.24 0.00e+0 115/128 (89.84%) CLN3;NPC2;IDUA;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.37uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 1.11uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.37uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 1.11uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM 6H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM 6H