Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJFRCT)

Drug Name
Tasisulam Drug Info
Synonyms Tasisulam sodium; LY-573636; LY-573636 sodium; LY-573636Na; Apoptosis stimulator (cancer), Lilly
Cross-matching ID
PubChem CID
10160238
CAS Number
CAS 519055-62-0
TTD Drug ID
D0X0KM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Viral myocarditis -1.76 4.20e-2 53/60 (88.33%) SGCG;HLA-DOB;CASP9;...
Inflammatory bowel disease -1.81 2.92e-2 58/65 (89.23%) IL23A;TGFB2;IL13;...
Synaptic vesicle cycle -1.85 1.71e-2 63/78 (80.77%) NAPA;STX2;TCIRG1;...
Autoimmune thyroid disease -1.87 1.35e-2 46/53 (86.79%) HLA-E;FASLG;CD80;...
Leishmaniasis -1.88 1.05e-2 67/77 (87.01%) MAPK13;IRAK1;TGFB2;...
Asthma -1.97 2.10e-3 25/31 (80.65%) HLA-DRA;IL5;FCER1G;...
Graft-versus-host disease -2.00 2.63e-3 32/42 (76.19%) HLA-E;FASLG;KLRD1;...
Protein digestion and absorption -2.01 3.50e-3 78/103 (75.73%) CELA3B;CTRL;ATP1B2;...
Allograft rejection -2.03 5.25e-3 32/38 (84.21%) HLA-E;FASLG;CD80;...
Type I diabetes mellitus -2.10 0.00e+0 38/43 (88.37%) PTPRN;LTA;HLA-E;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H