Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJFWB7)

Drug Name
SLV-313 Drug Info
Synonyms L001624
Cross-matching ID
PubChem CID
9887537
ChEBI ID
CHEMBL221692
CAS Number
CAS 222551-17-9
TTD Drug ID
D03ZZH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.06 7.94e-3 34/36 (94.44%) PCNA;MCM4;MCM6;...
Nitrogen metabolism -1.74 3.36e-2 16/17 (94.12%) CA14;CA8;CA6;...
Pentose and glucuronate interconversions -1.74 3.58e-2 17/34 (50%) UGT2B15;UGT2B28;UGT2B4;...
Retinol metabolism -1.75 3.85e-2 41/68 (60.29%) RDH5;CYP1A1;RDH11;...
Sphingolipid metabolism -1.80 2.02e-2 32/49 (65.31%) PLPP1;CERS6;SGMS1;...
Renin-angiotensin system -1.83 1.98e-2 20/23 (86.96%) CPA3;ENPEP;ANPEP;...
alpha-Linolenic acid metabolism -1.84 2.12e-2 17/25 (68%) PLA2G3;ACOX3;PLA2G4C;...
Primary bile acid biosynthesis -1.93 6.94e-3 15/17 (88.24%) SCP2;AKR1D1;CYP39A1;...
Steroid hormone biosynthesis -1.93 8.67e-3 43/61 (70.49%) CYP1A1;HSD17B7;DHRS11;...
Arachidonic acid metabolism -1.96 1.16e-2 48/61 (78.69%) PTGS1;GGT1;ALOX12B;...
Peroxisome -1.97 1.73e-2 72/82 (87.8%) PEX14;ABCD3;PEX16;...
Linoleic acid metabolism -2.08 1.16e-2 21/29 (72.41%) PLA2G3;PLA2G4C;PLA2G6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H