Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJHLSD)

• Drug Name: Famciclovir Drug Info
• Synonyms: FCV; Famciclovirum; Famvir; Oravir; BRL 42810; IN1338; Anti-Farnesyl Rabbit pAb; BRL-42810; Famciclovirum [INN-Latin]; Famvir (TN); Famciclovir [USAN:BAN:INN]; Famciclovir (JAN/USAN/INN); [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate; Diacetyl 6-deoxy-9-(4-hydroxy-3-hydroxymethyl-but-1-yl)guanine; 1,3-Propanediol, 2-(2-(2-amino-9H-purin-9-yl)ethyl)-, diacetate (ester); 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate (ester); 2-(2-(2-amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate; 2-(acetoxymethyl)-4-(2-amino-4,5-dihydro-9H-purin-9-yl)butyl acetate; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate; 2-[2-(2-amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate; 9-(4-acetoxy-3-(acetoxymethyl)but-1-yl)-2-aminopurine; 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine
• Therapeutic Class: Antiviral Agents
• Cross-matching ID:
  PubChem CID: 3324
  ChEBI ID: CHEMBL880
  CAS Number: CAS 104227-87-4
  TTD Drug ID: D0VT8P
  VARIDT Drug ID: DR01431
  INTEDE Drug ID: DR0679
  ACDINA Drug ID: D00264

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mitophagy	-1.61	4.01e-2	56/68 (82.35%)	JUN;CSNK2B;TBC1D17;...
Glycolysis / Gluconeogenesis	-1.64	3.70e-2	56/67 (83.58%)	LDHB;ADH6;ALDOB;...
Pathways of neurodegeneration	-1.64	3.66e-2	354/475 (74.53%)	FZD1;CHRM3;ATP5MC1;...
Measles	-1.64	3.76e-2	133/139 (95.68%)	IRAK4;IL1B;CDK6;...
Protein processing in endoplasmic reticulum	-1.65	3.58e-2	127/171 (74.27%)	DNAJB2;RPN2;HSPA2;...
Alzheimer disease	-1.66	3.29e-2	279/369 (75.61%)	FZD1;CHRM3;ATP5MC1;...
Retinol metabolism	-1.66	3.43e-2	41/68 (60.29%)	RDH11;CYP2C18;ADH6;...
Lipid and atherosclerosis	-1.66	3.37e-2	190/215 (88.37%)	PLCB4;CASP7;NCF2;...
Primary bile acid biosynthesis	-1.67	3.15e-2	15/17 (88.24%)	ACOX2;AMACR;SCP2;...
Drug metabolism	-1.68	2.78e-2	78/151 (51.66%)	UGT2B4;HPGDS;ADH1A;...
RIG-I-like receptor signaling pathway	-1.69	2.51e-2	64/70 (91.43%)	MAPK8;MAP3K7;NFKB1;...
Huntington disease	-1.73	1.76e-2	233/306 (76.14%)	NDUFA7;PSMB1;SLC1A3;...
Viral protein interaction with cytokine and cytokine re...	-1.74	1.59e-2	84/100 (84%)	PPBP;IL2RB;TNFRSF10B;...
Ferroptosis	-1.78	1.05e-2	36/41 (87.8%)	FTL;SLC7A11;TFRC;...
Prion disease	-1.81	9.69e-3	209/273 (76.56%)	NDUFA7;PSMB1;C6;...
NOD-like receptor signaling pathway	-1.84	7.16e-3	145/181 (80.11%)	CASR;JUN;PLCB1;...
Legionellosis	-1.84	7.67e-3	51/57 (89.47%)	NFKB1;CASP1;SAR1B;...
Parkinson disease	-1.84	8.26e-3	176/249 (70.68%)	COX5A;MAPK8;TUBB;...
Mineral absorption	-1.85	7.95e-3	48/60 (80%)	TF;FTH1;MT1M;...
Necroptosis	-1.85	7.59e-3	113/159 (71.07%)	IL1B;STAT2;GLUD1;...
Coronavirus disease	-1.88	3.58e-3	215/232 (92.67%)	C8A;RPS27;RPS15A;...
Non-alcoholic fatty liver disease	-1.92	2.65e-3	126/155 (81.29%)	IL6;COX5A;MAPK8;...
Antigen processing and presentation	-1.92	0.00e+0	60/78 (76.92%)	HLA-DRB1;HLA-F;CTSS;...
Ribosome	-1.94	0.00e+0	113/158 (71.52%)	RPL3;RPL21;RPS27L;...
Epithelial cell signaling in Helicobacter pylori infect...	-2.00	0.00e+0	62/70 (88.57%)	RAC1;NFKB1;ATP6V0E1;...
Rheumatoid arthritis	-2.01	0.00e+0	78/93 (83.87%)	ATP6V0E1;ATP6V1C1;ATP6V1H;...
Tyrosine metabolism	-2.06	0.00e+0	30/36 (83.33%)	FAH;ADH6;GOT2;...
IL-17 signaling pathway	-2.16	0.00e+0	84/94 (89.36%)	CASP3;CXCL10;FADD;...
Oxidative phosphorylation	-2.21	0.00e+0	93/133 (69.92%)	NDUFA9;COX8A;NDUFB7;...
TNF signaling pathway	-2.26	0.00e+0	103/112 (91.96%)	CASP8;PIK3R3;AKT3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼