Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJKFNU)

Drug Name
DCC-2036 Drug Info
Synonyms
REBASTINIB; DCC-2036; 1020172-07-9; DCC-2036 (Rebastinib); DCC 2036; CHEBI:62166; UNII-75017Q6I97; Rebastinib(DCC-2036); 4-(4-(3-(3-(tert-butyl)-1-(quinolin-6-yl)-1H-pyrazol-5-yl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; DCC2036; DP-1919; 4-[4-({[3-Tert-Butyl-1-(Quinolin-6-Yl)-1h-Pyrazol-5-Yl]carbamoyl}amino)-3-Fluorophenoxy]-N-Methylpyridine-2-Carboxamide; 75017Q6I97; 4-[4-[(5-Tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide,4-methylbenzenesulfonic acid;4-[4-[(
Cross-matching ID
PubChem CID
25066467
ChEBI ID
CHEMBL62166
CAS Number
CAS 1020172-07-9
TTD Drug ID
D0E0NM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Hematopoietic cell lineage 2.24 0.00e+0 90/99 (90.91%) CD44;CD3D;ITGA6;...
Rheumatoid arthritis 2.09 0.00e+0 78/93 (83.87%) CCL2;ATP6V0E2;TGFB1;...
Malaria 2.07 0.00e+0 44/50 (88%) CCL2;TGFB1;SDC2;...
Inflammatory bowel disease 2.07 0.00e+0 58/65 (89.23%) TGFB1;MAF;TGFB2;...
Cell adhesion molecules 2.01 0.00e+0 118/148 (79.73%) CD99;ITGA6;SDC2;...
Focal adhesion 1.92 1.91e-3 180/201 (89.55%) PDGFC;CAV1;PIK3CD;...
ECM-receptor interaction 1.89 3.28e-3 80/88 (90.91%) CD44;ITGA6;COL4A5;...
Allograft rejection 1.86 1.00e-2 32/38 (84.21%) HLA-DPA1;HLA-DQA1;HLA-DRA;...
Proteoglycans in cancer 1.83 1.66e-2 172/205 (83.9%) CD44;CAV1;PIK3CD;...
Graft-versus-host disease 1.82 1.49e-2 32/42 (76.19%) HLA-DPA1;HLA-DQA1;IL1A;...
Toxoplasmosis 1.81 1.36e-2 103/112 (91.96%) ITGA6;TGFB1;CASP8;...
Viral myocarditis 1.79 1.72e-2 53/60 (88.33%) SGCB;CAV1;CASP8;...
Vibrio cholerae infection 1.79 1.59e-2 44/50 (88%) ATP6V0E2;PRKCA;GNAS;...
Asthma 1.77 1.64e-2 25/31 (80.65%) HLA-DPA1;HLA-DQA1;HLA-DRA;...
Regulation of actin cytoskeleton 1.77 1.53e-2 185/218 (84.86%) PDGFC;PIK3CD;ITGA6;...
Tuberculosis 1.75 1.94e-2 159/180 (88.33%) TGFB1;CASP8;ITGB2;...
Th1 and Th2 cell differentiation 1.75 1.82e-2 80/92 (86.96%) JAG1;NFATC3;CD3D;...
Rap1 signaling pathway 1.73 2.10e-2 184/210 (87.62%) PDGFC;PIK3CD;ID1;...
Type I diabetes mellitus 1.72 2.23e-2 38/43 (88.37%) CPE;HLA-DPA1;HLA-DQA1;...
Salmonella infection 1.71 2.29e-2 198/249 (79.52%) S100A10;PIK3CD;CASP8;...
Various types of N-glycan biosynthesis 1.69 2.89e-2 26/39 (66.67%) HEXB;RPN2;STT3A;...
Th17 cell differentiation 1.69 2.87e-2 95/107 (88.79%) NFATC3;CD3D;TGFB1;...
Viral protein interaction with cytokine and cytokine re... 1.68 2.94e-2 84/100 (84%) CXCL14;CCL2;CCR7;...
Hippo signaling pathway 1.68 2.92e-2 120/186 (64.52%) AREG;TGFB1;ID1;...
Cytokine-cytokine receptor interaction 1.66 3.35e-2 246/295 (83.39%) CXCL14;IL32;CCL2;...
Gap junction 1.65 3.71e-2 72/88 (81.82%) PDGFC;GJA1;GUCY1A1;...
Renal cell carcinoma 1.65 3.74e-2 68/69 (98.55%) PIK3CD;TGFB1;SLC2A1;...
Pathways in cancer 1.65 3.65e-2 474/531 (89.27%) GSTT1;JAG1;PIK3CD;...
Phagosome 1.64 3.68e-2 118/152 (77.63%) ATP6V0E2;ITGB2;ITGAV;...
Arginine and proline metabolism 1.64 3.82e-2 39/50 (78%) CKB;ALDH2;SMS;...
Linoleic acid metabolism -1.78 1.55e-2 21/29 (72.41%) CYP2C8;CYP2C9;CYP3A4;...
Tyrosine metabolism -1.81 1.29e-2 30/36 (83.33%) TPO;TAT;ADH6;...
Metabolism of xenobiotics by cytochrome P450 -1.98 1.55e-3 49/77 (63.64%) UGT2B15;CYP2F1;GSTT2;...
Retinol metabolism -1.99 1.94e-3 41/68 (60.29%) CYP2C18;ADH6;UGT2B15;...
Complement and coagulation cascades -2.00 2.58e-3 76/85 (89.41%) SERPING1;C3AR1;SERPINA5;...
Ovarian steroidogenesis -2.04 3.87e-3 41/51 (80.39%) CYP2J2;LDLR;CYP19A1;...
Steroid hormone biosynthesis -2.29 0.00e+0 43/61 (70.49%) AKR1D1;CYP19A1;AKR1C3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 3.33uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H