Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJLUFM)

Drug Name	phenamil Drug Info
Cross-matching ID	PubChem CID 135403792 ChEBI ID CHEMBL211502 CAS Number CAS 2038-35-9 TTD Drug ID D05OEV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Fructose and mannose metabolism	2.07	0.00e+0	30/33 (90.91%)	PFKFB3;SORD;AKR1B10;...
Bladder cancer	1.91	2.45e-2	40/41 (97.56%)	MYC;E2F2;CDKN2A;...
Folate biosynthesis	1.86	3.26e-2	23/26 (88.46%)	AKR1B10;QDPR;GCH1;...
Glycosaminoglycan degradation	-1.76	4.08e-2	19/19 (100%)	HYAL3;HYAL2;HEXA;...
Parkinson disease	-1.79	4.42e-2	176/249 (70.68%)	ITPR2;NDUFB4;KIF5B;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	15uM	6H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H, 24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H, 24H