Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJLV03)

Drug Name
Vapiprost Drug Info
Synonyms Vapiprost hydrochloride; GR-32191; GR-32191B; SN-309
Cross-matching ID
PubChem CID
6918030
ChEBI ID
CHEMBL65030
CAS Number
CAS 85505-64-2
TTD Drug ID
D03ZVW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.19 0.00e+0 110/124 (88.71%) PLK1;ABL1;MCM4;...
Mismatch repair 1.82 4.69e-2 22/23 (95.65%) MLH1;MSH2;MLH3;...
Homologous recombination 1.79 4.39e-2 35/41 (85.37%) PALB2;RBBP8;MRE11;...
DNA replication 1.77 4.39e-2 34/36 (94.44%) POLE2;MCM4;MCM5;...
Pentose and glucuronate interconversions 1.75 4.54e-2 17/34 (50%) AKR1B10;UGT2B15;RPE;...
Spliceosome 1.75 4.14e-2 101/150 (67.33%) HSPA1A;RBMX;SRSF3;...
Fatty acid degradation -1.69 4.17e-2 40/43 (93.02%) ECI1;ACSBG2;ECHS1;...
Type I diabetes mellitus -1.69 4.42e-2 38/43 (88.37%) IFNG;HLA-DRA;TNF;...
Synaptic vesicle cycle -1.70 4.72e-2 63/78 (80.77%) SLC18A3;ATP6V0A1;CLTA;...
Oxidative phosphorylation -1.70 4.97e-2 93/133 (69.92%) COX5A;NDUFS3;COX7C;...
Primary immunodeficiency -1.74 3.39e-2 33/38 (86.84%) CD3D;PTPRC;ADA;...
Salivary secretion -1.76 3.11e-2 76/93 (81.72%) CALML3;ATP1A1;CALML4;...
Lysosome -1.89 6.45e-3 115/128 (89.84%) LIPA;GNPTAB;SLC11A1;...
Antigen processing and presentation -1.90 7.53e-3 60/78 (76.92%) KLRD1;IFNG;CD4;...
Rheumatoid arthritis -1.92 2.26e-3 78/93 (83.87%) ATP6V0A4;MMP1;CXCL12;...
Hematopoietic cell lineage -2.00 2.82e-3 90/99 (90.91%) ITGA1;IL1R2;GP1BA;...
Allograft rejection -2.06 0.00e+0 32/38 (84.21%) HLA-DOB;IL5;IL12B;...
Phagosome -2.16 0.00e+0 118/152 (77.63%) ATP6V1G1;PIK3C3;MSR1;...
Graft-versus-host disease -2.25 0.00e+0 32/42 (76.19%) KLRD1;IFNG;HLA-DRA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H