Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJP5YF)

Drug Name
Levodropropizine Drug Info
Synonyms
Levodropropizine; 99291-25-5; (S)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol; Levdropropizine; (-)-Dropropizine; Levotuss; Danka; Levodropropizina; Levodropropizinum; (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol; Rapitux; UNII-3O31P6T4G3; Levodropropizinum [INN-Latin]; Levodropropizina [INN-Spanish]; 99291-24-4; Levodropropizine [INN]; DF 526; CHEBI:82722; 3O31P6T4G3; S(-)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol; (-)-(S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol; Levodropropizine (INN); 1,2-Propanediol, 3-(4-phenyl-1-pipe
Cross-matching ID
PubChem CID
65859
ChEBI ID
CHEMBL82722
CAS Number
CAS 99291-25-5
TTD Drug ID
D0X5WJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.24 0.00e+0 34/36 (94.44%) RFC3;RFC5;DNA2;...
Fanconi anemia pathway 2.16 0.00e+0 36/54 (66.67%) BRCA1;FANCL;RMI1;...
Cell cycle 2.02 3.46e-3 110/124 (88.71%) CCNA2;ORC6;SKP2;...
Spliceosome 1.89 6.48e-3 101/150 (67.33%) PRPF4;LSM6;TRA2A;...
Steroid biosynthesis 1.83 1.14e-2 19/20 (95%) CYP51A1;NSDHL;DHCR7;...
Phenylalanine metabolism 1.82 1.04e-2 14/17 (82.35%) MAOB;DDC;AOC3;...
Homologous recombination 1.80 1.04e-2 35/41 (85.37%) BARD1;BRCA1;RAD54B;...
Base excision repair 1.78 1.55e-2 29/33 (87.88%) FEN1;POLE3;POLE2;...
Mismatch repair 1.67 3.34e-2 22/23 (95.65%) RFC3;RFC5;MSH6;...
Oocyte meiosis 1.64 4.09e-2 90/129 (69.77%) IGF1;FBXO5;CDK1;...
Progesterone-mediated oocyte maturation 1.60 4.99e-2 75/100 (75%) IGF1;CCNA2;CDK1;...
Prion disease -1.63 4.81e-2 209/273 (76.56%) HSPA1A;CSNK2B;CAV2;...
Antigen processing and presentation -1.63 4.99e-2 60/78 (76.92%) IFI30;LGMN;HSPA2;...
Kaposi sarcoma-associated herpesvirus infection -1.64 4.83e-2 172/193 (89.12%) TCF7L1;CLEC2B;HLA-F;...
Parkinson disease -1.67 4.03e-2 176/249 (70.68%) SEM1;PSMC4;PSMA5;...
Pertussis -1.67 4.14e-2 64/76 (84.21%) RELA;CASP1;RHOA;...
Endocrine and other factor-regulated calcium reabsorpti... -1.70 3.44e-2 49/53 (92.45%) CALB1;PRKACA;PLCB2;...
Bacterial invasion of epithelial cells -1.71 2.95e-2 59/77 (76.62%) PIK3CA;RHOA;ACTB;...
Hematopoietic cell lineage -1.73 2.50e-2 90/99 (90.91%) CD1B;CD4;CD5;...
Graft-versus-host disease -1.73 2.63e-2 32/42 (76.19%) HLA-DMB;HLA-DQB1;TNF;...
Huntington disease -1.75 2.19e-2 233/306 (76.14%) SEM1;PSMC4;DNALI1;...
Fluid shear stress and atherosclerosis -1.79 8.01e-3 123/139 (88.49%) ITGB3;ACVR1;SDC2;...
Complement and coagulation cascades -1.83 4.73e-3 76/85 (89.41%) ITGB2;C2;BDKRB1;...
AGE-RAGE signaling pathway in diabetic complications -1.87 2.02e-3 97/100 (97%) NRAS;PLCB2;RELA;...
Oxidative phosphorylation -1.90 2.16e-3 93/133 (69.92%) NDUFA10;ATP5MG;SDHA;...
Other glycan degradation -1.93 2.33e-3 13/18 (72.22%) NEU1;HEXA;MANBA;...
Epithelial cell signaling in Helicobacter pylori infect... -1.94 2.52e-3 62/70 (88.57%) ATP6V0A1;ATP6AP1;ATP6V0B;...
Rheumatoid arthritis -1.94 2.75e-3 78/93 (83.87%) TGFB1;ATP6V0D1;ATP6V0C;...
Endocytosis -1.98 1.51e-3 198/252 (78.57%) WWP1;SPG21;RAB11B;...
Collecting duct acid secretion -2.00 1.68e-3 22/27 (81.48%) ATP6V0A1;ATP6V1B2;SLC4A1;...
Proteasome -2.03 1.89e-3 44/46 (95.65%) PSMB1;IFNG;SEM1;...
Phagosome -2.05 2.16e-3 118/152 (77.63%) ITGB3;TUBB1;STX7;...
Synaptic vesicle cycle -2.07 2.52e-3 63/78 (80.77%) ATP6V0A1;CACNA1B;ATP6V0B;...
Vibrio cholerae infection -2.08 3.03e-3 44/50 (88%) ATP6V0A4;ADCY3;SEC61A1;...
Ferroptosis -2.13 3.78e-3 36/41 (87.8%) CP;GPX4;GCLM;...
Mitophagy -2.13 5.04e-3 56/68 (82.35%) FOXO3;MRAS;TBC1D15;...
Lysosome -2.16 0.00e+0 115/128 (89.84%) ARSA;NAGPA;IDUA;...
Mineral absorption -2.30 0.00e+0 48/60 (80%) HEPH;TRPV6;SLC30A1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 2.5uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 24H