Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJPSIL)

Drug Name
Dapivirine Drug Info
Synonyms
Dapivirinum; R 147681; R147681; TMC 120; TMC120; GEL-002; R-147681; TMC-120; TMC120-R147681; TMC-120/R-147681; 4-((4-((2,4,6-Trimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile; 4-({4-[(2,4,6-Trimethylphenyl)amino]pyrimidin-2-yl}amino)benzenecarbonitrile; 4-[4-(2,4,6-TRIMETHYL-PHENYLAMINO)-PYRIMIDIN-2-YLAMINO]-BENZONITRILE; 4-[[4-(2,4,6-trimethylanilino)pyrimidin-2-yl]amino]benzonitrile
Cross-matching ID
PubChem CID
214347
CAS Number
CAS 244767-67-7
TTD Drug ID
D0DC6U
INTEDE Drug ID
DR1822

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pyruvate metabolism -1.66 4.05e-2 41/47 (87.23%) ME1;ME3;PDHB;...
Tryptophan metabolism -1.67 3.82e-2 35/42 (83.33%) CYP1A2;DHTKD1;ACAT2;...
Renin secretion -1.69 2.98e-2 61/69 (88.41%) GNAS;CLCA4;PPP3CC;...
Lipid and atherosclerosis -1.71 3.07e-2 190/215 (88.37%) CASP3;SRC;TNFRSF10B;...
Phenylalanine metabolism -1.72 3.08e-2 14/17 (82.35%) MAOB;GLYAT;PAH;...
Pathogenic Escherichia coli infection -1.76 2.54e-2 152/197 (77.16%) IL1R1;ARF6;CASP3;...
Protein export -1.78 2.11e-2 17/23 (73.91%) SRP54;SRP9;SEC61A2;...
Tyrosine metabolism -1.78 2.13e-2 30/36 (83.33%) ADH6;ADH1A;DBH;...
Drug metabolism -1.80 2.15e-2 78/151 (51.66%) MPO;NME7;FMO1;...
Retinol metabolism -1.82 1.99e-2 41/68 (60.29%) CYP2C8;DHRS3;BCO1;...
Primary bile acid biosynthesis -1.84 2.24e-2 15/17 (88.24%) CYP7B1;ACOX2;CYP7A1;...
IL-17 signaling pathway -1.85 2.98e-2 84/94 (89.36%) IL17RA;CASP3;MAPK1;...
Legionellosis -1.90 2.98e-2 51/57 (89.47%) CYCS;IL18;HSPA6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H