Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJTDK9)

Drug Name
Ki16425 Drug Info
Synonyms SCHEMBL13385834
Cross-matching ID
PubChem CID
10367662
ChEBI ID
CHEMBL361501
CAS Number
CAS 355025-24-0
TTD Drug ID
D02LXI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 1.96 2.54e-2 19/20 (95%) LIPA;TM7SF2;DHCR24;...
TNF signaling pathway -1.71 4.52e-2 103/112 (91.96%) DNM1L;MAPK8;MAPK3;...
Arginine and proline metabolism -1.75 3.50e-2 39/50 (78%) ARG2;OAT;DAO;...
Pancreatic secretion -1.80 1.60e-2 87/102 (85.29%) PLA2G1B;ADCY2;PNLIPRP1;...
Cytokine-cytokine receptor interaction -1.83 9.34e-3 246/295 (83.39%) IL5;CXCL2;CTF1;...
Carbohydrate digestion and absorption -1.85 5.61e-3 37/47 (78.72%) PLCB1;LCT;PLCB4;...
JAK-STAT signaling pathway -1.86 7.01e-3 146/162 (90.12%) IL5;CTF1;IL9R;...
Maturity onset diabetes of the young -1.96 0.00e+0 21/26 (80.77%) INS;NEUROD1;SLC2A2;...
Glycine, serine and threonine metabolism -1.96 0.00e+0 31/40 (77.5%) SDS;DAO;ALAS2;...
Mineral absorption -2.11 0.00e+0 48/60 (80%) SLC11A2;ATOX1;MT1M;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H