Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJV2EK)

Drug Name
Dasatinib Drug Info
Synonyms
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
3062316
ChEBI ID
CHEMBL1421
CAS Number
CAS 302962-49-8
TTD Drug ID
D0E6XR
VARIDT Drug ID
DR00182
INTEDE Drug ID
DR0423
ACDINA Drug ID
D00171

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Histidine metabolism 2.22 0.00e+0 16/22 (72.73%) HNMT;MAOA;ALDH9A1;...
Propanoate metabolism 2.01 0.00e+0 30/34 (88.24%) ALDH6A1;ACACB;ACAT2;...
Antigen processing and presentation 2.00 0.00e+0 60/78 (76.92%) CD74;RFX5;TAPBP;...
Butanoate metabolism 1.98 0.00e+0 23/28 (82.14%) ALDH5A1;BDH2;ACSM3;...
Valine, leucine and isoleucine degradation 1.98 0.00e+0 42/48 (87.5%) ALDH6A1;ALDH9A1;ALDH2;...
Peroxisome 1.93 0.00e+0 72/82 (87.8%) CAT;IDH1;ECH1;...
Tryptophan metabolism 1.86 4.07e-3 35/42 (83.33%) CAT;KYNU;MAOA;...
Fatty acid degradation 1.84 4.74e-3 40/43 (93.02%) ALDH9A1;ALDH2;ACAT2;...
Oxidative phosphorylation 1.83 5.27e-3 93/133 (69.92%) ATP5MC2;NDUFB1;NDUFB11;...
beta-Alanine metabolism 1.83 4.74e-3 25/30 (83.33%) ALDH6A1;ALDH9A1;ALDH2;...
Glyoxylate and dicarboxylate metabolism 1.82 6.90e-3 23/30 (76.67%) CAT;GLUL;SHMT1;...
ABC transporters 1.82 6.32e-3 37/45 (82.22%) ABCA8;DEFB1;ABCA5;...
Tyrosine metabolism 1.81 6.57e-3 30/36 (83.33%) MAOA;COMT;DCT;...
Ascorbate and aldarate metabolism 1.80 6.10e-3 15/30 (50%) ALDH9A1;ALDH2;ALDH3A2;...
Steroid hormone biosynthesis 1.79 7.59e-3 43/61 (70.49%) AKR1C3;AKR1C2;AKR1C1;...
Staphylococcus aureus infection 1.76 1.01e-2 72/95 (75.79%) CFB;CFI;FGG;...
Metabolism of xenobiotics by cytochrome P450 1.75 9.49e-3 49/77 (63.64%) EPHX1;AKR1C1;MGST2;...
Pentose and glucuronate interconversions 1.73 1.53e-2 17/34 (50%) AKR1B10;UGT2B28;DCXR;...
Asthma 1.70 2.05e-2 25/31 (80.65%) PRG2;HLA-DRA;HLA-DRB1;...
Glycine, serine and threonine metabolism 1.69 2.18e-2 31/40 (77.5%) PHGDH;MAOA;SHMT1;...
Bile secretion 1.69 2.08e-2 68/90 (75.56%) EPHX1;SLC4A4;ATP1A1;...
Systemic lupus erythematosus 1.68 2.20e-2 45/135 (33.33%) C3;C1R;C1S;...
Other glycan degradation 1.68 2.23e-2 13/18 (72.22%) NEU1;AGA;MANBA;...
Primary bile acid biosynthesis 1.67 2.41e-2 15/17 (88.24%) AMACR;ACOX2;HSD17B4;...
Nitrogen metabolism 1.66 2.54e-2 16/17 (94.12%) CPS1;CA12;GLUL
Type I diabetes mellitus 1.66 2.48e-2 38/43 (88.37%) CPE;HLA-F;HLA-DRA;...
Salivary secretion 1.65 2.78e-2 76/93 (81.72%) MUC5B;ATP1A1;PLCB1;...
Phenylalanine metabolism 1.63 3.22e-2 14/17 (82.35%) MAOA;ALDH3A1;MAOB;...
One carbon pool by folate 1.62 3.34e-2 15/20 (75%) DHFR;SHMT1;ALDH1L1;...
Coronavirus disease 1.60 3.70e-2 215/232 (92.67%) CFB;FGG;OAS1;...
Small cell lung cancer -1.63 3.89e-2 90/92 (97.83%) BIRC3;COL4A6;CYCS;...
Malaria -1.64 3.65e-2 44/50 (88%) TGFB1;CCL2;MET;...
Endocytosis -1.67 2.71e-2 198/252 (78.57%) CHMP5;RUFY2;PRKCZ;...
Ribosome biogenesis in eukaryotes -1.72 1.82e-2 52/108 (48.15%) LSG1;TBL3;TCOF1;...
PI3K-Akt signaling pathway -1.74 1.36e-2 317/354 (89.55%) GRB2;CD19;GSK3B;...
p53 signaling pathway -1.74 1.32e-2 63/73 (86.3%) CCNE1;CDKN1A;CDK6;...
Adherens junction -1.75 1.39e-2 63/71 (88.73%) PTPRB;MAP3K7;IGF1R;...
Arrhythmogenic right ventricular cardiomyopathy -1.75 1.41e-2 70/77 (90.91%) CACNB4;CACNG4;CACNB3;...
Renal cell carcinoma -1.76 1.43e-2 68/69 (98.55%) PTPN11;PDGFB;RAC1;...
Bladder cancer -1.80 5.94e-3 40/41 (97.56%) MMP9;SRC;MMP2;...
Apelin signaling pathway -1.80 6.34e-3 117/137 (85.4%) ITPR3;GNB2;NRAS;...
Tight junction -1.81 6.79e-3 130/169 (76.92%) ARHGAP17;RAB8B;MYL6;...
AGE-RAGE signaling pathway in diabetic complications -1.88 2.44e-3 97/100 (97%) MMP2;MAPK9;IL6;...
Bacterial invasion of epithelial cells -1.88 2.64e-3 59/77 (76.62%) RHOG;ACTR3B;ARPC4;...
Dilated cardiomyopathy -1.88 2.88e-3 86/96 (89.58%) LMNA;DES;TPM3;...
Regulation of actin cytoskeleton -1.90 2.11e-3 185/218 (84.86%) MRAS;PIP5K1A;SRC;...
Proteasome -1.91 1.17e-3 44/46 (95.65%) PSMA7;PSMD11;PSMA4;...
Salmonella infection -1.95 1.32e-3 198/249 (79.52%) RHOG;ACTR3B;PFN2;...
TGF-beta signaling pathway -1.97 1.51e-3 81/94 (86.17%) INHBB;BMP2;BMP6;...
Colorectal cancer -1.98 1.76e-3 84/86 (97.67%) MAPK9;BAK1;RAC1;...
Hippo signaling pathway -2.05 0.00e+0 120/186 (64.52%) FZD6;GLI2;BMP2;...
Proteoglycans in cancer -2.07 0.00e+0 172/205 (83.9%) MRAS;SRC;PXN;...
Hypertrophic cardiomyopathy -2.19 0.00e+0 81/90 (90%) PRKAB2;IL6;LMNA;...
ECM-receptor interaction -2.23 0.00e+0 80/88 (90.91%) THBS4;CD44;VWF;...
Focal adhesion -2.31 0.00e+0 180/201 (89.55%) PIP5K1A;SRC;THBS4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 1.11uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 1.11uM 72H
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 1.11uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H