Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJXDGC)

• Drug Name: Cefaclor Drug Info
• Synonyms: Alenfral; Alfacet; Alfatil; CCL; Ceclor; Cefaclorum; Distaclor; Kefolor; Panacef; Panoral; Alfatil Kapseln; Cefaclor anhydrous; Cefaclor hydrate; Cefaclor monohydrate; Dystaclor MR; Kefolor Suspension; Muco Panoral; Lilly 99638 hydrate; Alenfral (TN); Ceclor (TN); Cefaclor (JP15); Cefaclor (USP); Distaclor (TN); Keflor (TN); L-Kefral; Raniclor (TN); S-6472; Cefaclor-1-wasser; Cefaclor [USAN:INN:BAN:JAN]; Ceclor, Distaclor, Keflor, Raniclor, Cefaclor; (6R,7R)-7-((R)-2-Amino-2-phenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monohydrate; (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate; (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid; 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid monohydrate; 7-(2-Amino-2-phenyl-acetylamino)-3-chloro-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7beta-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-3,4-didehydrocepham-4-carboxylic acid
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 51039
  ChEBI ID: CHEMBL680
  CAS Number: CAS 53994-73-3
  TTD Drug ID: D0PW7C
  VARIDT Drug ID: DR00259
  ACDINA Drug ID: D00104

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Spliceosome	2.00	6.90e-3	101/150 (67.33%)	LSM5;HSPA2;SNRPG;...
Proteasome	1.97	3.45e-3	44/46 (95.65%)	PSMD13;PSMB5;PSMD2;...
Cell cycle	1.96	4.60e-3	110/124 (88.71%)	CCND2;SMC1A;PLK1;...
DNA replication	1.96	5.18e-3	34/36 (94.44%)	PCNA;RPA3;POLE3;...
Linoleic acid metabolism	1.74	3.59e-2	21/29 (72.41%)	PLAAT3;CYP2C8;CYP2E1;...
Systemic lupus erythematosus	1.70	4.83e-2	45/135 (33.33%)	C1QB;C1S;C2;...
RNA polymerase	1.70	4.24e-2	23/31 (74.19%)	POLR2L;POLR2I;POLR2A;...
Complement and coagulation cascades	1.70	3.71e-2	76/85 (89.41%)	SERPING1;CFB;SERPINA5;...
Ribosome biogenesis in eukaryotes	1.68	4.07e-2	52/108 (48.15%)	IMP3;POP7;NOP10;...
Steroid biosynthesis	1.68	3.66e-2	19/20 (95%)	MSMO1;HSD17B7;DHCR24;...
mRNA surveillance pathway	1.67	3.64e-2	71/98 (72.45%)	CLP1;EIF4A3;NXT2;...
Nucleotide excision repair	1.64	4.72e-2	40/47 (85.11%)	PCNA;RPA3;RAD23B;...
Nicotinate and nicotinamide metabolism	-1.76	3.23e-2	25/35 (71.43%)	NNT;NADK;BST1;...
Wnt signaling pathway	-1.77	3.52e-2	124/166 (74.7%)	FBXW11;BAMBI;LRP5;...
Basal cell carcinoma	-1.84	2.05e-2	41/63 (65.08%)	FZD10;FZD5;CDKN1A;...
ECM-receptor interaction	-1.88	1.72e-2	80/88 (90.91%)	THBS4;LAMB2;LAMA5;...
Fructose and mannose metabolism	-1.91	1.23e-2	30/33 (90.91%)	FBP1;HKDC1;TPI1;...
Thyroid hormone signaling pathway	-1.93	1.64e-2	112/121 (92.56%)	MED24;PLCG1;MAP2K2;...
Protein digestion and absorption	-1.95	1.85e-2	78/103 (75.73%)	MME;MEP1A;COL18A1;...
Glucagon signaling pathway	-1.98	2.46e-2	89/107 (83.18%)	ITPR1;PRKAA1;EP300;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼