Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJYDVK)

Drug Name
Cariprazine Drug Info
Synonyms
Cariprazine; 839712-12-8; RGH-188; RGH 188; Cariprazine(RGH188); UNII-F6RJL8B278; F6RJL8B278; CHEMBL3085826; 3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea; Cariprazine [USAN:INN]; Reagila; MP-214; MP 214; Cariprazine (USAN/INN); Cariprazine (RGH-188); C21H32Cl2N4O; SCHEMBL184342; SCHEMBL184343; GTPL7671; SCHEMBL7861573; CHEMBL2028019; CHEBI:90933; HSDB 8310; DTXSID80232867; KPWSJANDNDDRMB-QAQDUYKDSA-N; MolPort-039-139-594; BDBM263449; BCP14691; BDBM50443101; BDBM50382290; ZINC38309313; 3526AH
Cross-matching ID
PubChem CID
11154555
ChEBI ID
CHEMBL5986307
CAS Number
CAS 839712-12-8
TTD Drug ID
D05XGO
INTEDE Drug ID
DR0276
ACDINA Drug ID
D00100

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycolysis / Gluconeogenesis 2.07 0.00e+0 56/67 (83.58%) DLD;PGAM1;ENO2;...
Citrate cycle (TCA cycle) 1.97 0.00e+0 30/30 (100%) DLD;DLST;CS;...
Focal adhesion 1.95 0.00e+0 180/201 (89.55%) FN1;FLNA;LAMB1;...
Central carbon metabolism in cancer 1.94 0.00e+0 67/70 (95.71%) PGAM1;PKM;SIRT3;...
Steroid biosynthesis 1.84 1.21e-2 19/20 (95%) LSS;CYP27B1;CYP51A1;...
Amoebiasis 1.84 1.01e-2 99/102 (97.06%) FN1;LAMB1;CD14;...
Lysine degradation 1.78 2.59e-2 51/63 (80.95%) DLD;DLST;PLOD2;...
Ovarian steroidogenesis -1.79 3.61e-2 41/51 (80.39%) PLA2G4C;CGA;PTGS2;...
Folate biosynthesis -1.83 1.64e-2 23/26 (88.46%) GGH;MOCOS;ALPL;...
Pentose and glucuronate interconversions -1.95 0.00e+0 17/34 (50%) SORD;UGT2B4;DCXR;...
Arachidonic acid metabolism -2.02 0.00e+0 48/61 (78.69%) CYP4F2;CBR3;CYP2C9;...
Steroid hormone biosynthesis -2.13 0.00e+0 43/61 (70.49%) UGT2B4;HSD17B12;COMT;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H