Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJZ0AM)

• Drug Name: GERANYLGERANYL DIPHOSPHATE Drug Info
• Synonyms: Geranylgeranyl pyrophosphate; Geranylgeranyl diphosphate; GGDP; 6699-20-3; geranylgeranyl-PP; GGPP; UNII-N21T0D88LX; (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl trihydrogen diphosphate; N21T0D88LX; Geranylgeraniol diphosphate; CHEBI:48861; all-trans-Geranylgeranyl pyrophosphate; all-trans-Geranylgeranyl diphosphate; Diphosphoric acid, mono(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl) ester, (E,E,E)-; Geranylgeranyl pyrophosphate ammonium salt; 2-trans,6-trans,10-trans-geranylgeranyl diphosphate
• Cross-matching ID:
  PubChem CID: 447277
  ChEBI ID: CHEMBL48861
  CAS Number: CAS 6699-20-3
  TTD Drug ID: D0QX6B

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.33	0.00e+0	76/85 (89.41%)	FGG;CFB;C3;...
TNF signaling pathway	-1.78	3.92e-2	103/112 (91.96%)	FAS;RPS6KA4;ICAM1;...
Sulfur metabolism	-1.81	3.59e-2	9/10 (90%)	MPST;ETHE1;SUOX;...
Proteasome	-1.81	4.79e-2	44/46 (95.65%)	PSMC2;PSMB5;PSMA6;...
Mineral absorption	-2.34	0.00e+0	48/60 (80%)	ATP1B3;ATP1A2;SLC26A3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲