Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMJZVPB)

Drug Name
ENMD-2076 Drug Info
Synonyms
ENMD-2076; 934353-76-1; ENMD 2076; (E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine; UNII-J6U9WP10T7; ENMD2076; J6U9WP10T7; CHEMBL482968; 6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]pyrimidin-4-amine; 6-(4-METHYL-1-PIPERAZINYL)-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-[(1E)-2-PHENYLETHENYL]-4-PYRIMIDINAMINE; ENMD-981693; MLS006011042; SCHEMBL596481; GTPL7885; SCHEMBL15668060; SCHEMBL10122872; ENND-2076; EX-A235; DTXSID60239430; MolPort-009-679-391; AOB87159
Cross-matching ID
PubChem CID
16041424
ChEBI ID
CHEMBL482968
CAS Number
CAS 934353-76-1
TTD Drug ID
D0S7HM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.29 0.00e+0 19/20 (95%) SQLE;LSS;DHCR24;...
Ascorbate and aldarate metabolism 2.19 0.00e+0 15/30 (50%) ALDH7A1;AKR1A1;UGT2B15;...
Sulfur metabolism 1.95 9.46e-3 9/10 (90%) TST;SELENBP1;MPST;...
Lysosome 1.86 2.13e-2 115/128 (89.84%) TPP1;CTSA;CTSD;...
Histidine metabolism 1.82 2.27e-2 16/22 (72.73%) HNMT;ALDH7A1;ALDH3B1;...
RNA transport -1.68 4.70e-2 128/186 (68.82%) SENP2;SEC13;GEMIN6;...
Focal adhesion -1.69 4.74e-2 180/201 (89.55%) CAPN2;ITGA8;MAPK1;...
ECM-receptor interaction -1.70 4.68e-2 80/88 (90.91%) DMP1;ITGA5;SDC1;...
Spliceosome -1.74 3.19e-2 101/150 (67.33%) PRPF18;SRSF1;SNRPB2;...
Ribosome biogenesis in eukaryotes -1.77 2.28e-2 52/108 (48.15%) GAR1;MPHOSPH10;MDN1;...
IL-17 signaling pathway -1.82 1.42e-2 84/94 (89.36%) IL13;ELAVL1;MAP3K7;...
Cell cycle -1.93 0.00e+0 110/124 (88.71%) CDC7;CDC14B;TGFB1;...
Mismatch repair -1.97 0.00e+0 22/23 (95.65%) MSH6;RPA1;POLD2;...
Epithelial cell signaling in Helicobacter pylori infect... -2.12 0.00e+0 62/70 (88.57%) MAPK9;MAPK13;MAPK10;...
DNA replication -2.17 0.00e+0 34/36 (94.44%) RPA1;MCM3;RNASEH2B;...
Proteasome -2.49 0.00e+0 44/46 (95.65%) SEM1;PSMA5;PSMD3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H