Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMK1CZJ)

Drug Name
Ingenol mebutate Drug Info
Synonyms
Picato; Ingenol 3-angelate; 75567-37-2; PEP-005; PEP005; 3-Angeloylingenol; UNII-7686S50JAH; PEP 005; 3-Ingenyl angelate; Ingenol-3-angelate; 7686S50JAH; Picato (TN); Euphorbia factor H1; Euphorbia factor An1; Ingenol mebutate [USAN:INN]; [dihydroxy-(hydroxymethyl)-tetramethyl-oxo-[ ]yl] (Z)-2-methylbut-2-enoate; I3A; Ingenol-3- angelate; Ingenol mebutate (USAN); (Z)-2-methylbut-2-enoate; SCHEMBL2526605; GTPL7443; CHEMBL1863513; HSDB 8308; VDJHFHXMUKFKET-WDUFCVPESA-N; MolPort-003-941-761; AN-262; POL-103A
Cross-matching ID
PubChem CID
6918670
ChEBI ID
CHEMBL66913
CAS Number
CAS 75567-37-2
TTD Drug ID
D0E9KA
VARIDT Drug ID
DR01483
ACDINA Drug ID
D01160

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.64 0.00e+0 84/94 (89.36%) MMP1;CXCL8;PTGS2;...
Rheumatoid arthritis 2.48 0.00e+0 78/93 (83.87%) MMP1;CXCL8;CXCL1;...
TNF signaling pathway 2.44 0.00e+0 103/112 (91.96%) PTGS2;CXCL1;CCL20;...
Cytokine-cytokine receptor interaction 2.36 0.00e+0 246/295 (83.39%) CXCL8;INHBA;CXCL1;...
NF-kappa B signaling pathway 2.31 0.00e+0 90/104 (86.54%) CXCL8;PTGS2;PLAU;...
Epithelial cell signaling in Helicobacter pylori infect... 2.29 0.00e+0 62/70 (88.57%) CXCL8;CXCL1;MET;...
Viral protein interaction with cytokine and cytokine re... 2.29 0.00e+0 84/100 (84%) CXCL8;CXCL1;CCL20;...
NOD-like receptor signaling pathway 2.27 0.00e+0 145/181 (80.11%) CXCL8;CXCL1;IL1B;...
ECM-receptor interaction 2.17 0.00e+0 80/88 (90.91%) LAMC2;LAMB3;SDC4;...
Kaposi sarcoma-associated herpesvirus infection 2.16 0.00e+0 172/193 (89.12%) CXCL8;PTGS2;CXCL1;...
Malaria 2.04 0.00e+0 44/50 (88%) CXCL8;IL1B;MET;...
Lipid and atherosclerosis 2.02 0.00e+0 190/215 (88.37%) MMP1;CXCL8;CXCL1;...
Salmonella infection 2.01 0.00e+0 198/249 (79.52%) CXCL8;IL1B;NFKBIA;...
Osteoclast differentiation 2.00 0.00e+0 117/127 (92.13%) FOSL1;RELB;IL1B;...
Amoebiasis 1.99 7.34e-4 99/102 (97.06%) CXCL8;LAMC2;CXCL1;...
Focal adhesion 1.99 6.88e-4 180/201 (89.55%) LAMC2;LAMB3;ITGB5;...
Yersinia infection 1.99 6.47e-4 120/137 (87.59%) CXCL8;IL1B;NFKBIA;...
Small cell lung cancer 1.99 1.22e-3 90/92 (97.83%) LAMC2;PTGS2;LAMB3;...
C-type lectin receptor signaling pathway 1.97 1.74e-3 93/104 (89.42%) PTGS2;RELB;IL1B;...
Human papillomavirus infection 1.96 2.20e-3 284/331 (85.8%) LAMC2;PTGS2;LAMB3;...
Lysosome 1.93 2.62e-3 115/128 (89.84%) CTSB;CTSL;GALC;...
JAK-STAT signaling pathway 1.92 2.50e-3 146/162 (90.12%) LIF;PDGFA;CDKN1A;...
Phagosome 1.91 2.39e-3 118/152 (77.63%) ITGB5;CTSL;ITGA5;...
Bacterial invasion of epithelial cells 1.90 2.29e-3 59/77 (76.62%) MET;ARPC1B;ITGA5;...
Pertussis 1.90 2.20e-3 64/76 (84.21%) CXCL8;CXCL5;IL1B;...
Pathogenic Escherichia coli infection 1.89 2.96e-3 152/197 (77.16%) CXCL8;IL1B;NFKBIA;...
Toll-like receptor signaling pathway 1.89 2.85e-3 94/104 (90.38%) CXCL8;IL1B;NFKBIA;...
Shigellosis 1.89 2.75e-3 180/246 (73.17%) CXCL8;IL1B;TNIP1;...
RIG-I-like receptor signaling pathway 1.87 3.42e-3 64/70 (91.43%) CXCL8;NFKBIA;ISG15;...
Hematopoietic cell lineage 1.86 3.67e-3 90/99 (90.91%) IL1B;CD55;ITGA6;...
Cysteine and methionine metabolism -1.56 4.72e-2 43/50 (86%) AHCYL2;GOT1;BCAT2;...
One carbon pool by folate -1.58 4.01e-2 15/20 (75%) MTHFD1;ALDH1L1;AMT;...
Homologous recombination -1.60 3.54e-2 35/41 (85.37%) SEM1;BABAM1;BRCC3;...
Fatty acid degradation -1.61 3.16e-2 40/43 (93.02%) EHHADH;GCDH;ALDH3A2;...
Ribosome -1.62 3.00e-2 113/158 (71.52%) RPLP0;RPS10;RPS23;...
Lysine degradation -1.64 2.70e-2 51/63 (80.95%) PRDM2;SETDB1;KMT5A;...
Alanine, aspartate and glutamate metabolism -1.66 2.25e-2 27/37 (72.97%) ALDH4A1;ASPA;GLS2;...
Propanoate metabolism -1.66 2.36e-2 30/34 (88.24%) ACADS;LDHB;ACOX1;...
Mismatch repair -1.69 1.93e-2 22/23 (95.65%) RFC3;PCNA;MSH2;...
Butanoate metabolism -1.70 1.88e-2 23/28 (82.14%) OXCT1;AACS;ACAT1;...
Steroid biosynthesis -1.73 1.24e-2 19/20 (95%) LSS;EBP;FDFT1;...
Glyoxylate and dicarboxylate metabolism -1.76 1.10e-2 23/30 (76.67%) MMUT;AMT;CS;...
Valine, leucine and isoleucine degradation -1.77 1.24e-2 42/48 (87.5%) BCKDHA;EHHADH;DLD;...
Terpenoid backbone biosynthesis -1.80 9.46e-3 18/22 (81.82%) ICMT;PDSS2;MVK;...
RNA transport -1.86 4.14e-3 128/186 (68.82%) NCBP1;NDC1;NXF3;...
Fanconi anemia pathway -1.93 1.66e-3 36/54 (66.67%) RPA2;TOP3A;HES1;...
Cell cycle -2.02 0.00e+0 110/124 (88.71%) ANAPC1;MCM7;CHEK1;...
Glycine, serine and threonine metabolism -2.17 0.00e+0 31/40 (77.5%) AMT;MAOB;SHMT2;...
DNA replication -2.22 0.00e+0 34/36 (94.44%) RNASEH2A;RPA2;POLE2;...
Spliceosome -2.27 0.00e+0 101/150 (67.33%) PRPF6;SF3A3;NCBP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H