Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMK3SAF)

Drug Name
BI-D1870 Drug Info
Synonyms
501437-28-1; 2-((3,5-difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one; 2-(3,5-difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one; C19H23F2N5O2; 2-(3,5-difluoro-4-hydroxyphenylamino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one; BI-D 1870; CHEMBL573107; GTPL8038; SCHEMBL13881333; CTK8I8998; BDBM25017; DTXSID40648506; BID1870; MolPort-008-266-821; HMS3244D11; HMS3244C12; HMS3244C11; BCPP000343; HMS3651D17; BCP01977; EX-A2471; NSC747342
Cross-matching ID
PubChem CID
25023738
ChEBI ID
CHEMBL573107
CAS Number
CAS 501437-28-1
TTD Drug ID
D02VBF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.21 0.00e+0 52/108 (48.15%) PWP2;LSG1;RPP38;...
Proteasome 2.17 0.00e+0 44/46 (95.65%) PSMD8;PSMD12;PSMA4;...
Steroid biosynthesis 1.85 3.02e-2 19/20 (95%) SC5D;MSMO1;DHCR24;...
RNA transport 1.79 4.82e-2 128/186 (68.82%) EIF3B;EIF4G1;EIF5;...
Apoptosis 1.78 4.54e-2 126/168 (75%) BIRC3;CASP7;CTSK;...
Nicotine addiction -1.71 4.71e-2 32/40 (80%) GRIA2;GABRA4;GABRB2;...
Neutrophil extracellular trap formation -1.85 3.38e-2 101/189 (53.44%) TLR2;PRKCB;HDAC9;...
Cardiac muscle contraction -1.94 8.46e-3 64/87 (73.56%) MYH6;MYH7;TNNT2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H