Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMK459I)

Drug Name
9H-beta-Carboline-3-carboxylic acid ethyl ester Drug Info
Synonyms
Ethyl beta-carboline-3-carboxylate; beta-CCE; 74214-62-3; Ethyl 9H-pyrido[3,4-b]indole-3-carboxylate; beta-Carboline-3-carboxylic acid ethyl ester; UNII-HYW8K5N21Y; Ethyl 9H-pyrido(3,4-b)indole-3-carboxylate; HYW8K5N21Y; Ro 15-2538; CHEMBL11709; 9H-Pyrido(3,4-b)indole-3-carboxylic acid, ethyl ester; MLS000069492; CHEMBL454606; KOVRZNUMIKACTB-UHFFFAOYSA-N; SMR000059107; 9H-Pyrido[3,4-b]indole-3-carboxylic acid, ethyl ester; b-cce; Ethylbeta-carboline-3-carboxylate; Beta CCE
Cross-matching ID
PubChem CID
105078
ChEBI ID
CHEMBL454606
CAS Number
CAS 74214-62-3
TTD Drug ID
D01RLF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 1.98 1.06e-2 110/124 (88.71%) CCNB1;RAD21;CCNB2;...
Thiamine metabolism 1.91 1.06e-2 12/15 (80%) AK5;AK4;TPK1;...
One carbon pool by folate -1.83 2.53e-2 15/20 (75%) ALDH1L1;MTHFD2L;ATIC;...
PPAR signaling pathway -1.84 2.85e-2 66/74 (89.19%) SCD5;CYP7A1;ADIPOQ;...
Fat digestion and absorption -1.85 2.85e-2 35/43 (81.4%) SCARB1;PLPP2;FABP1;...
Glycine, serine and threonine metabolism -1.87 3.80e-2 31/40 (77.5%) DAO;AGXT;CBS;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H