Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMK54YG)

• Drug Name: Griseofulvin Drug Info
• Synonyms: Amudane; Delmofulvina; Fulcin; Fulcine; Fulvicin; FulvicinUF; Fulvina; Fulvinil; Fulvistatin; Fungivin; Greosin;Gresfeed; Gricin; Grifulin; Grifulvin; GrisPEG; Grisactin; Griscofulvin; Grisefuline; Griseo; Griseofulvina; Griseofulvine; Griseofulvinum; Griseomix; Griseostatin; Grisetin; Grisofulvin; Grisovin; Grizeofulvin; Grysio; Guservin; Lamoryl; Likuden; Likunden; Murfulvin; Poncyl; Spirofulvin; Sporostatin; Xuanjing; Curling fact or; Curling factor; Fulvican grisactin; Fulvicin U F; Grifulvin V; Gris PEG; Grisactin Ultra; Grise ostatin; Griseofulvin forte; Grisovin FP; Interacts with polymerized microtubules and associated proteins; Sporostatin xan; Biogrisin-FP; FULVICIN P/G 165; FULVICIN P/G 330;Fulvicin Bolus (Veterinary); Fulvicin P/G; Fulvicin U/F; Fulvidex (Veterinary); GRISEOFULVIN, MICROCRYSTALLINE; GRISEOFULVIN, ULTRAMICROCRYSTALLINE; Gris-PEG; Griseofulvin and Alpha-IFN; Griseofulvin-forte; Griseofulvina [INN-Spanish]; Griseofulvine [INN-French]; Griseofulvinum [INN-Latin]; Grisovin (TN); NP-002466; Neo-Fulcin; ULTRAGRIS-165; ULTRAGRIS-330; USAF SC-2; Fulvicin-P/G; Fulvicin-U-F; Fulvicin-U/F; Fulvicin-U/F (Veterinary); Griseofulvin [USAN:INN:BAN:JAN]; (+)-Griseofulvin; 7-Chloro-4,6,2'-trimethoxy-6'-methylgris-2'-en-3,4'-dione
• Therapeutic Class: Antifungal Agents
• Cross-matching ID:
  PubChem CID: 441140
  ChEBI ID: CHEMBL27779
  CAS Number: CAS 126-07-8
  TTD Drug ID: D0C1SF
  INTEDE Drug ID: DR0791
  ACDINA Drug ID: D00306

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cell cycle	2.07	0.00e+0	110/124 (88.71%)	CDC20;TGFB1;PLK1;...
Spliceosome	1.94	1.41e-2	101/150 (67.33%)	PUF60;LSM5;HNRNPM;...
Ribosome biogenesis in eukaryotes	1.86	2.82e-2	52/108 (48.15%)	DKC1;PWP2;NOP56;...
Parkinson disease	-1.68	4.20e-2	176/249 (70.68%)	TUBB;VDAC2;MAOB;...
Phenylalanine metabolism	-1.70	3.94e-2	14/17 (82.35%)	MIF;MAOA;GLYAT;...
Citrate cycle (TCA cycle)	-1.71	4.01e-2	30/30 (100%)	PDHB;IDH1;SUCLG1;...
Antigen processing and presentation	-1.73	2.84e-2	60/78 (76.92%)	HLA-E;HSPA8;LGMN;...
IL-17 signaling pathway	-1.75	2.34e-2	84/94 (89.36%)	MAPK1;CXCL3;TRAF3IP2;...
Oxidative phosphorylation	-1.76	2.37e-2	93/133 (69.92%)	COX5A;NDUFB8;NDUFB3;...
Tyrosine metabolism	-1.79	1.80e-2	30/36 (83.33%)	MIF;DCT;DBH;...
Drug metabolism	-1.83	1.93e-2	78/151 (51.66%)	CYP3A4;ADH1A;UPP1;...
Metabolism of xenobiotics by cytochrome P450	-1.85	1.68e-2	49/77 (63.64%)	CYP3A5;ADH1C;UGT2A3;...
Glycolysis / Gluconeogenesis	-1.85	2.10e-2	56/67 (83.58%)	ADH7;DLD;AKR1A1;...
Retinol metabolism	-1.92	1.40e-2	41/68 (60.29%)	CYP3A5;RETSAT;ADH1C;...
Pyruvate metabolism	-1.98	5.26e-3	41/47 (87.23%)	GLO1;ADH7;ME2;...
Tryptophan metabolism	-2.12	0.00e+0	35/42 (83.33%)	AOC1;ALDH9A1;MAOB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼