Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMK7DA8)

Drug Name
Tagatose Drug Info
Synonyms Naturalose; Naturlose; Spherix; D-tagatose
Cross-matching ID
PubChem CID
439312
ChEBI ID
CHEMBL4249
TTD Drug ID
D01TVR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 1.92 2.48e-2 110/124 (88.71%) PLK1;CCNB2;SMC1A;...
RNA polymerase 1.89 2.07e-2 23/31 (74.19%) POLR3K;POLR3B;POLR3G;...
Pentose phosphate pathway -1.69 4.53e-2 25/30 (83.33%) RBKS;RPE;PGLS;...
Antigen processing and presentation -1.70 3.44e-2 60/78 (76.92%) HSPA6;NFYC;TAP2;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.73 2.84e-2 79/89 (88.76%) CD28;JAK2;BATF;...
Th1 and Th2 cell differentiation -1.76 2.37e-2 80/92 (86.96%) HLA-DPA1;JAK2;MAPK10;...
Cell adhesion molecules -1.77 2.37e-2 118/148 (79.73%) NLGN4X;CD58;CLDN8;...
Herpes simplex virus 1 infection -1.77 2.53e-2 165/498 (33.13%) CARD9;TNFRSF14;TAP2;...
Graft-versus-host disease -1.78 2.56e-2 32/42 (76.19%) CD28;HLA-DPA1;HLA-DOA;...
Other glycan degradation -1.84 1.18e-2 13/18 (72.22%) ENGASE;MANBA;MAN2C1;...
Allograft rejection -2.00 0.00e+0 32/38 (84.21%) CD40LG;CD28;HLA-DPA1;...
Lysosome -2.03 0.00e+0 115/128 (89.84%) GALNS;M6PR;CLTCL1;...
Type I diabetes mellitus -2.03 0.00e+0 38/43 (88.37%) CD28;HLA-DPA1;HSPD1;...
Autoimmune thyroid disease -2.05 0.00e+0 46/53 (86.79%) CD40LG;CD28;HLA-DPA1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H