Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMK9BRV)

• Drug Name: Pidotimod Drug Info
• Synonyms: Pgt-1A; 117241-40-4; 3-Pyroglutamylthiazolidine-4-carboxylic acid; 3-(5-oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid; NSC678119; 3-((5-Oxo-2-pyrrolidinyl)carbonyl)-4-thiazolidinecarboxylic acid; 3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid; 4-Thiazolidinecarboxylic acid, 3-((5-oxo-2-pyrrolidinyl)carbonyl)-; C9H12N2O4S; 3-(5-oxoprolyl)-1,3-thiazolidine-4-carboxylic acid; ACMC-20emtr; ACMC-209vwo; AC1L3FWE; MLS006011471; SCHEMBL9342892; CTK0H7615; MolPort-004-328-744; 4-Thiazolidinecarboxylicacid, 3-[[(2S)-5-
• Cross-matching ID:
  PubChem CID: 65944
  ChEBI ID: CHEMBL94618
  CAS Number: CAS 121808-62-6
  TTD Drug ID: D04YCE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Signaling pathways regulating pluripotency of stem cell...	1.91	4.07e-2	110/143 (76.92%)	BMP4;ID1;ID3;...
Dilated cardiomyopathy	-1.89	3.93e-2	86/96 (89.58%)	TPM3;ITGA5;PRKACA;...
Cortisol synthesis and secretion	-1.94	2.94e-2	58/65 (89.23%)	HSD3B1;STAR;PRKACA;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼