General Information of Drug (ID: DMKA8R4)

Drug Name
SB 228357 Drug Info
Synonyms SB-228357; SB228357
Cross-matching ID
PubChem CID
443390
ChEBI ID
CHEMBL14276
CAS Number
CAS 181629-93-6
TTD Drug ID
D05NWH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Malaria 2.17 0.00e+0 44/50 (88%) CXCL8;HBB;COMP;...
Allograft rejection 2.12 0.00e+0 32/38 (84.21%) HLA-DRB1;HLA-DRA;HLA-B;...
NF-kappa B signaling pathway 2.09 0.00e+0 90/104 (86.54%) CXCL8;CXCL2;TNFAIP3;...
Graft-versus-host disease 2.08 0.00e+0 32/42 (76.19%) HLA-DRB1;HLA-DRA;HLA-B;...
Legionellosis 2.05 0.00e+0 51/57 (89.47%) HSPA1A;CXCL8;CXCL2;...
Th17 cell differentiation 2.05 0.00e+0 95/107 (88.79%) NFKBIA;AHR;IL6ST;...
Antigen processing and presentation 2.03 0.00e+0 60/78 (76.92%) HSPA1A;HSPA6;HLA-DRB1;...
Asthma 2.00 0.00e+0 25/31 (80.65%) HLA-DRB1;HLA-DRA;HLA-DQB1;...
TNF signaling pathway 1.98 0.00e+0 103/112 (91.96%) CXCL2;TNFAIP3;NFKBIA;...
Inflammatory bowel disease 1.98 0.00e+0 58/65 (89.23%) NFKB1;HLA-DRB1;IFNGR1;...
Autoimmune thyroid disease 1.97 0.00e+0 46/53 (86.79%) HLA-DRB1;HLA-DRA;HLA-B;...
Rheumatoid arthritis 1.97 0.00e+0 78/93 (83.87%) CXCL8;CXCL2;HLA-DRB1;...
Longevity regulating pathway 1.94 0.00e+0 90/151 (59.6%) HSPA1A;CRYAB;HSPA6;...
Lipid and atherosclerosis 1.93 0.00e+0 190/215 (88.37%) HSPA1A;CXCL8;CXCL2;...
IL-17 signaling pathway 1.92 0.00e+0 84/94 (89.36%) CXCL8;CXCL2;TNFAIP3;...
Leishmaniasis 1.90 0.00e+0 67/77 (87.01%) NFKBIA;CYBA;NFKB1;...
Ferroptosis 1.87 6.40e-4 36/41 (87.8%) SAT1;SLC39A8;SLC7A11;...
JAK-STAT signaling pathway 1.87 6.05e-4 146/162 (90.12%) MYC;MCL1;CSF2RB;...
Phagosome 1.86 1.72e-3 118/152 (77.63%) CYBA;COMP;ACTB;...
Th1 and Th2 cell differentiation 1.86 2.18e-3 80/92 (86.96%) NFKBIA;JAG1;NFKB1;...
Type I diabetes mellitus 1.82 3.63e-3 38/43 (88.37%) HLA-DRB1;HLA-DRA;HLA-B;...
Kaposi sarcoma-associated herpesvirus infection 1.82 3.46e-3 172/193 (89.12%) CXCL8;CXCL2;MYC;...
Cytokine-cytokine receptor interaction 1.80 5.21e-3 246/295 (83.39%) CXCL8;CXCL2;CSF2RB;...
Protein processing in endoplasmic reticulum 1.74 1.45e-2 127/171 (74.27%) HERPUD1;HSPA1A;CRYAB;...
Circadian rhythm 1.73 1.39e-2 26/31 (83.87%) BHLHE40;PER1;PRKAA1;...
Fluid shear stress and atherosclerosis 1.72 1.51e-2 123/139 (88.49%) CYBA;ARHGEF2;ACTB;...
Epithelial cell signaling in Helicobacter pylori infect... 1.72 1.53e-2 62/70 (88.57%) CXCL8;CXCL2;NFKBIA;...
Osteoclast differentiation 1.72 1.56e-2 117/127 (92.13%) FHL2;RELB;FOSB;...
Salmonella infection 1.70 1.69e-2 198/249 (79.52%) CXCL8;MYC;NFKBIA;...
Chronic myeloid leukemia 1.70 1.63e-2 72/76 (94.74%) MYC;NFKBIA;NRAS;...
Mineral absorption -1.93 2.63e-2 48/60 (80%) SLC26A6;ATP1B1;HMOX2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H