Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKDS1C)

Drug Name
Rimcazole Drug Info
Synonyms
Rimcazol; Rimcazolum; Rimcazole [INN]; BW 234U; BW-234U; Rimcazol [INN-Spanish]; Rimcazolum [INN-Latin]; Cis-9-(3-(3,5-dimethyl-1-piperazinyl)propyl)carbazole; 9-[3-(Cis-3,5-Dimethyl-1-Piperazinyl)Propyl]Carbazole Hydrochloride; 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)propyl]carbazole dihydrochloride monohydrate; 9-[3-[(3R,5S)-3,5-dimethylpiperazin-1-yl]propyl]carbazole; 9-[3-[(3S,5R)-3,5-dimethylpiperazin-1-yl]propyl]carbazole
Cross-matching ID
PubChem CID
53389
ChEBI ID
CHEMBL275707
CAS Number
CAS 75859-04-0
TTD Drug ID
D0M9GE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.55 0.00e+0 19/20 (95%) MSMO1;DHCR24;SQLE;...
Terpenoid backbone biosynthesis 2.24 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
Biosynthesis of unsaturated fatty acids 2.19 0.00e+0 21/27 (77.78%) SCD;ELOVL6;FADS1;...
Systemic lupus erythematosus 2.10 0.00e+0 45/135 (33.33%) C7;CTSG;HLA-DPA1;...
Fatty acid biosynthesis 2.07 2.18e-3 16/18 (88.89%) FASN;ACACA;ACSL3;...
Glyoxylate and dicarboxylate metabolism 1.99 1.81e-3 23/30 (76.67%) ACAT2;GLUL;PCCA;...
Steroid hormone biosynthesis 1.95 4.67e-3 43/61 (70.49%) HSD17B7;AKR1C3;HSD11B1;...
Butanoate metabolism 1.91 6.81e-3 23/28 (82.14%) HMGCS1;ACAT2;ACSM3;...
Synthesis and degradation of ketone bodies 1.90 7.26e-3 9/10 (90%) HMGCS1;ACAT2
Metabolism of xenobiotics by cytochrome P450 1.84 1.42e-2 49/77 (63.64%) HSD11B1;GSTA1;EPHX1;...
Glycolysis / Gluconeogenesis 1.83 1.68e-2 56/67 (83.58%) ALDOC;AKR1A1;ENO2;...
Pentose phosphate pathway 1.83 1.72e-2 25/30 (83.33%) ALDOC;G6PD;TKT;...
Valine, leucine and isoleucine degradation 1.82 1.76e-2 42/48 (87.5%) HMGCS1;ACAT2;ALDH3A2;...
Pentose and glucuronate interconversions 1.81 1.71e-2 17/34 (50%) AKR1A1;DCXR;GUSB;...
Renin-angiotensin system 1.81 1.67e-2 20/23 (86.96%) CTSG;CPA3;CTSA;...
Lysosome 1.80 1.84e-2 115/128 (89.84%) NPC2;LIPA;NEU1;...
Cholesterol metabolism 1.79 1.86e-2 44/50 (88%) LDLR;NPC2;LIPA;...
Tryptophan metabolism 1.77 2.12e-2 35/42 (83.33%) ACAT2;ALDH3A2;KMO;...
Leishmaniasis 1.76 2.18e-2 67/77 (87.01%) TLR4;HLA-DPA1;FCGR2C;...
Phagosome 1.74 2.89e-2 118/152 (77.63%) TLR4;HLA-DPA1;FCGR2C;...
PPAR signaling pathway 1.74 2.80e-2 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Fructose and mannose metabolism 1.73 2.97e-2 30/33 (90.91%) ALDOC;PFKP;ALDOB;...
Ascorbate and aldarate metabolism 1.72 3.17e-2 15/30 (50%) AKR1A1;ALDH3A2;GUSB;...
Antigen processing and presentation 1.69 4.40e-2 60/78 (76.92%) HLA-DPA1;HSPA6;HLA-DRA;...
Staphylococcus aureus infection 1.68 4.70e-2 72/95 (75.79%) FGG;KRT18;CFD;...
Fc gamma R-mediated phagocytosis 1.68 4.61e-2 79/97 (81.44%) LYN;MARCKS;PRKCB;...
Glycosaminoglycan degradation 1.68 4.44e-2 19/19 (100%) GUSB;IDS;GNS;...
Neutrophil extracellular trap formation 1.67 4.59e-2 101/189 (53.44%) TLR4;FGG;CTSG;...
Vitamin digestion and absorption 1.66 4.88e-2 17/24 (70.83%) APOA1;TCN2;APOB;...
Glutathione metabolism 1.66 4.72e-2 43/57 (75.44%) G6PD;PGD;IDH1;...
Mineral absorption -1.79 3.17e-2 48/60 (80%) TRPM6;MT2A;SLC31A1;...
IL-17 signaling pathway -1.82 4.32e-2 84/94 (89.36%) CHUK;HSP90AA1;MAPK13;...
Protein export -1.95 1.73e-2 17/23 (73.91%) SPCS3;SEC11A;SRPRB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H