Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKEG49)

Drug Name
Fenthion Drug Info
Synonyms
Baytex; ENT 25,540; Fenthion 4E; Fenthion [BAN]; Fenthion [BSI:ISO]; Fenthion-methyl; Fenthione; Figuron; Lebaycid; Lebayeid; MPP (pesticide); Mercaptophos; Mosquitocide 700; Phenthion; Pro-Spot; Queletox; S 1752; Spotton; Sulfidophos; Talodex; Tiguvon; fenthion; 4-Methylmercapto-3-methylphenyl dimethyl thiophosphate; 55-38-9; B 29493; BAY 29493; Bay-Bassa; Baycid; Bayer 29493; Bayer 9007; Bayer S-1752; BL0L45OVKT; C10H15O3PS2; CCRIS 310; Caswell No. 456F; EINECS 200-231-9; Entex; HSDB 1403; NCI-C08651; OMS 2; UNII-BL0L45OVKT
Cross-matching ID
PubChem CID
3346
ChEBI ID
CHEMBL34761
CAS Number
CAS 55-38-9
INTEDE Drug ID
DR1945

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.99 1.21e-2 34/36 (94.44%) PCNA;RPA2;RFC2;...
Rap1 signaling pathway 1.89 4.25e-2 184/210 (87.62%) RAPGEF2;ANGPT1;ID1;...
Galactose metabolism -1.58 4.93e-2 26/31 (83.87%) PFKM;B4GALT1;HKDC1;...
Folate biosynthesis -1.61 3.83e-2 23/26 (88.46%) SPR;PTS;ALPG;...
D-Glutamine and D-glutamate metabolism -1.63 3.20e-2 5/5 (100%) GLUD2;GLUD1
Cholesterol metabolism -1.71 1.60e-2 44/50 (88%) SOAT2;ANGPTL3;ABCG5;...
Arachidonic acid metabolism -1.74 1.48e-2 48/61 (78.69%) PTGS1;PLA2G10;CYP4F2;...
Pyruvate metabolism -1.75 1.35e-2 41/47 (87.23%) ACYP2;ME1;ADH7;...
Butanoate metabolism -1.76 1.25e-2 23/28 (82.14%) ACAT1;ABAT;ACSM3;...
PPAR signaling pathway -1.76 1.32e-2 66/74 (89.19%) GK;FABP6;PLIN1;...
Phenylalanine metabolism -1.77 1.05e-2 14/17 (82.35%) GOT2;HPD;GOT1;...
Staphylococcus aureus infection -1.79 1.01e-2 72/95 (75.79%) KRT24;CAMP;HLA-DMB;...
Steroid biosynthesis -1.80 1.09e-2 19/20 (95%) HSD17B7;TM7SF2;SOAT2;...
Porphyrin and chlorophyll metabolism -1.82 9.85e-3 23/43 (53.49%) UGT2B17;HCCS;COX10;...
Arginine biosynthesis -1.84 8.01e-3 17/22 (77.27%) GOT2;GLUL;OTC;...
Drug metabolism -1.88 6.55e-3 78/151 (51.66%) ADH7;CYP2C8;HPRT1;...
Linoleic acid metabolism -1.88 7.21e-3 21/29 (72.41%) CYP2C8;PLA2G1B;PLA2G10;...
Tyrosine metabolism -1.96 2.67e-3 30/36 (83.33%) ADH7;GOT2;ADH5;...
Nicotinate and nicotinamide metabolism -1.98 3.00e-3 25/35 (71.43%) ENPP1;PNP;QPRT;...
Metabolism of xenobiotics by cytochrome P450 -1.98 3.43e-3 49/77 (63.64%) HSD11B1;ADH5;GSTO1;...
Complement and coagulation cascades -2.01 2.67e-3 76/85 (89.41%) C6;SERPING1;SERPINC1;...
Steroid hormone biosynthesis -2.07 1.60e-3 43/61 (70.49%) HSD11B2;HSD17B7;HSD11B1;...
Pentose and glucuronate interconversions -2.09 2.00e-3 17/34 (50%) UGT2A3;SORD;DCXR;...
Vitamin digestion and absorption -2.11 0.00e+0 17/24 (70.83%) PNLIP;MMACHC;SLC19A1;...
Fat digestion and absorption -2.13 0.00e+0 35/43 (81.4%) ACAT1;CLPS;PLA2G1B;...
Retinol metabolism -2.25 0.00e+0 41/68 (60.29%) ADH7;CYP2C8;ADH5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.66uM - 20uM 3H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H