Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKFQJP)

• Drug Name: Triflupromazine Drug Info
• Synonyms: Adazine; Fluopromazine; Fluorofen; Neoprin; Nivoman; Psyquil; Siquil; Trifluopromazine; Triflupromazina; Triflupromazinum;Vesprin; Vetame; Fluopromazine monohydrochloride; Trifluopromazine hydrochloride; Triflupromazine [INN]; Triflupromazina [INN-Spanish]; Triflupromazinum [INN-Latin]; Vesprin (TN); Triflupromazine (USP/INN)
• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 5568
  ChEBI ID: CHEMBL570
  CAS Number: CAS 146-54-3
  TTD Drug ID: D05NOS
  VARIDT Drug ID: DR01359

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.30	0.00e+0	19/20 (95%)	MSMO1;SQLE;LSS;...
Complement and coagulation cascades	1.93	5.62e-3	76/85 (89.41%)	SERPINA1;CD55;FGG;...
Ovarian steroidogenesis	1.89	7.50e-3	41/51 (80.39%)	GNAS;ALOX5;AKR1C3;...
Phagosome	1.86	1.12e-2	118/152 (77.63%)	SFTPA2;THBS2;CLEC7A;...
Acute myeloid leukemia	1.82	1.35e-2	66/67 (98.51%)	AKT3;PIK3CA;ITGAM;...
Biosynthesis of unsaturated fatty acids	1.81	1.31e-2	21/27 (77.78%)	SCD;FADS1;FADS2;...
Lysosome	1.81	1.29e-2	115/128 (89.84%)	SORT1;CTSD;DNASE2;...
Pentose phosphate pathway	1.80	1.41e-2	25/30 (83.33%)	G6PD;FBP1;PGD;...
Fc epsilon RI signaling pathway	1.80	1.25e-2	57/68 (83.82%)	ALOX5;LYN;AKT3;...
Cholesterol metabolism	1.77	2.02e-2	44/50 (88%)	APOC1;SORT1;LDLR;...
Terpenoid backbone biosynthesis	1.72	3.17e-2	18/22 (81.82%)	HMGCS1;IDI1;FDPS;...
GnRH secretion	1.72	3.37e-2	60/64 (93.75%)	KCNN4;AKT3;PLCB1;...
Type II diabetes mellitus	1.70	3.81e-2	42/46 (91.3%)	PIK3CA;PIK3R1;HK3;...
Vitamin digestion and absorption	1.70	3.53e-2	17/24 (70.83%)	SLC5A6;APOA1;SLC19A2;...
Fc gamma R-mediated phagocytosis	1.67	4.35e-2	79/97 (81.44%)	LYN;AKT3;FCGR2A;...
Legionellosis	-1.69	4.74e-2	51/57 (89.47%)	HSPA2;CLK4;HBS1L;...
Proteasome	-1.71	4.28e-2	44/46 (95.65%)	PSMD12;PSMA6;PSME3;...
DNA replication	-1.73	4.31e-2	34/36 (94.44%)	PRIM1;RFC4;POLD3;...
Mineral absorption	-2.06	8.29e-3	48/60 (80%)	ATP2B2;SLC26A3;VDR;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼
HEK293T	CVCL_0063	Homo sapiens	0.125uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼