Details of the Drug Pharmacogenomic Perturbation Atlas

BREQUINAR Drug Info

Brequinar; 96187-53-0; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; brequinarum [Latin]; Brequinar [INN]; Biphenquinate; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; Brequinarum [INN-Latin]; UNII-5XL19F49H6; C23H15F2NO2; NSC-368390; NSC 368390; 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid; PHEZJEYUWHETKO-UHFFFAOYSA-N; Dup 785; 5XL19F49H6; 6-FLUORO-2-(2'-FLUORO-1,1'-BIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID; brequinarum

Cross-matching ID

PubChem CID

57030

ChEBI ID

CHEMBL38434

CAS Number

CAS 96187-53-0

TTD Drug ID

D0N3XT

General Information of Drug (ID: DMKGM42)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Lysosome	2.27	0.00e+0	115/128 (89.84%)	NPC2;GAA;PSAP;...
p53 signaling pathway	2.23	0.00e+0	63/73 (86.3%)	CDKN1A;SESN1;BAX;...
Glutathione metabolism	1.98	0.00e+0	43/57 (75.44%)	GSTM3;G6PD;GSTT1;...
Other glycan degradation	1.96	0.00e+0	13/18 (72.22%)	NEU1;FUCA1;MAN2B1;...
Pentose phosphate pathway	1.85	2.18e-2	25/30 (83.33%)	G6PD;PFKL;ALDOC;...
Graft-versus-host disease	1.81	3.63e-2	32/42 (76.19%)	HLA-B;HLA-F;HLA-C;...
ABC transporters	1.80	3.11e-2	37/45 (82.22%)	ABCC5;ABCB6;DEFB1;...
Thyroid cancer	1.79	2.73e-2	36/37 (97.3%)	CDKN1A;BAX;TP53;...
Metabolism of xenobiotics by cytochrome P450	1.79	2.56e-2	49/77 (63.64%)	AKR7A2;GSTM3;GSTT1;...
Epstein-Barr virus infection	1.77	2.91e-2	189/202 (93.56%)	CDKN1A;HLA-B;BAX;...
Allograft rejection	1.71	4.52e-2	32/38 (84.21%)	HLA-B;HLA-F;HLA-C;...
Human immunodeficiency virus 1 infection	1.68	4.93e-2	189/212 (89.15%)	HLA-B;BAX;HLA-F;...
Spliceosome	-1.81	1.55e-2	101/150 (67.33%)	SRSF3;DHX8;MAGOHB;...
Ribosome biogenesis in eukaryotes	-1.90	1.16e-2	52/108 (48.15%)	GNL3L;DROSHA;NOP56;...
RNA transport	-2.13	0.00e+0	128/186 (68.82%)	GEMIN8;EIF4E;PABPC3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H